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Downregulated GTCPH IBH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women
Joint Authors
Yao, Shun
Ren, Zi
Zeng, Haitao
Liao, Jinli
Liu, Zhihao
He, Hao
Li, Xiao-Peng
Hu, Da-Jun
Huang, Zhenhua
Zhan, Hong
Luo, Ying
Yan, Quanneng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-01
Country of Publication
Egypt
No. of Pages
11
Abstract EN
Endothelial progenitor cells (EPCs) have endogenous endothelium-reparative potential, but obesity impairs EPCs.
Overweight premenopausal women have a normal number of circulating EPCs with functional activity, but whether EPCs in overweight postmenopausal women can repair obesity-related endothelial damage requires further investigation.
For this purpose, we examined the function and number of circulating EPCs, evaluated vascular endothelial function, and explored the underlying mechanism.
Compared with normal weight or overweight age-matched men, postmenopausal women (overweight or normal weight) had a diminished number of circulating EPCs and impaired vascular endothelial function, as detected by flow-mediated dilatation.
Moreover, GTCPH I expression and the nitric oxide level in overweight postmenopausal women and men were significantly decreased.
Together, our findings demonstrate that the number or function of circulating EPCs and endothelial function, which is partially regulated by the GTCPH I/BH4 signaling pathway, is not preserved in overweight postmenopausal women.
The GTCPH I/BH4 pathway in circulating EPCs may be a potential therapeutic target for endothelial injury in overweight postmenopausal women.
American Psychological Association (APA)
Luo, Ying& Huang, Zhenhua& Liao, Jinli& Liu, Zhihao& Li, Xiao-Peng& Yao, Shun…[et al.]. 2018. Downregulated GTCPH IBH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213430
Modern Language Association (MLA)
Luo, Ying…[et al.]. Downregulated GTCPH IBH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213430
American Medical Association (AMA)
Luo, Ying& Huang, Zhenhua& Liao, Jinli& Liu, Zhihao& Li, Xiao-Peng& Yao, Shun…[et al.]. Downregulated GTCPH IBH4 Pathway and Decreased Function of Circulating Endothelial Progenitor Cells and Their Relationship with Endothelial Dysfunction in Overweight Postmenopausal Women. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213430
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213430