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Intraparenchymal Neural StemProgenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review
Joint Authors
Huang, Xiaolin
Chen, Zhishui
Chen, Hong
Huang, Hailong
Qian, Kun
Li, Xin
Zheng, Yifeng
Han, Xiaohua
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-02
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Intraparenchymal transplantation of neural stem/progenitor cells (NSPCs) has been extensively investigated in animal models of ischemic stroke.
However, the reported therapeutic efficacy was inconsistent among studies.
To evaluate this situation, PubMed, Embase, and Web of Science databases were searched for preclinical studies using NSPC intraparenchymal transplantation in ischemic stroke animals.
Data of study quality score, neurobehavioral (mNSS, rotarod test, and cylinder test) and histological (infarct volume) outcomes, cell therapy-related serious adverse events, and related cellular mechanisms were extracted for meta-analysis and systematic review.
A total of 62 studies containing 73 treatment arms were included according to our criterion, with a mean quality score of 5.10 in 10.
Among these studies, almost half of the studies claimed no adverse events of tumorigenesis.
The finally pooled effect sizes for neurobehavioral and histological assessments were large (1.27 for mNSS, 1.63 for the rotarod test, 0.71 for the cylinder test, and 1.11 for infarct volume reduction).
With further analysis, it was found that the administration time poststroke, NSPC donor species, and transplantation immunogenicity had close correlations with the degree of infarct volume reduction.
The NSPC dosage delivered into the brain parenchyma was also negatively correlated with the effect of the cylinder test.
Intriguingly, endogenous apoptosis inhibition and axonal regeneration played the most critical role in intraparenchymal NSPC transplantation among the cellular mechanisms.
These results indicate that intraparenchymal NSPC transplantation is beneficial for neurobehavioral and histological improvement and is relatively safe for ischemic stroke animals.
Therefore, intraparenchymal NSPC transplantation is a promising treatment for stroke patients.
American Psychological Association (APA)
Huang, Hailong& Qian, Kun& Han, Xiaohua& Li, Xin& Zheng, Yifeng& Chen, Zhishui…[et al.]. 2018. Intraparenchymal Neural StemProgenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213434
Modern Language Association (MLA)
Huang, Hailong…[et al.]. Intraparenchymal Neural StemProgenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213434
American Medical Association (AMA)
Huang, Hailong& Qian, Kun& Han, Xiaohua& Li, Xin& Zheng, Yifeng& Chen, Zhishui…[et al.]. Intraparenchymal Neural StemProgenitor Cell Transplantation for Ischemic Stroke Animals: A Meta-Analysis and Systematic Review. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213434