Characterization of Human Mesenchymal Stem Cells Isolated from the Testis
Joint Authors
Tolosano, Emanuela
Revelli, Alberto
Buttiglieri, S.
van Pelt, Ans M. M.
Altruda, Fiorella
Fagoonee, Sharmila
De Chiara, Letizia
Famulari, Elvira Smeralda
van Daalen, Saskia K. M.
Silengo, Lorenzo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-03
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Mesenchymal stem cells hold great promise for regenerative medicine as they can be easily isolated from different sources such as adipose tissue, bone marrow, and umbilical cord blood.
Spontaneously arising pluripotent stem cells can be obtained in culture from murine spermatogonial stem cells (SSCs), while the pluripotency of the human counterpart remains a matter of debate.
Recent gene expression profiling studies have demonstrated that embryonic stem cell- (ESC-) like cells obtained from the human testis are indeed closer to mesenchymal stem cells (MSCs) than to pluripotent stem cells.
Here, we confirm that colonies derived from human testicular cultures, with our isolation protocol, are of mesenchymal origin and do not arise from spermatogonial stem cells (SSCs).
The testis, thus, provides an important and accessible source of MSCs (tMSCs) that can be potentially used for nephrotoxicity testing in vitro.
We further demonstrate, for the first time, that tMSCs are able to secrete microvesicles that could possibly be applied to the treatment of various chronic diseases, such as those affecting the kidney.
American Psychological Association (APA)
De Chiara, Letizia& Famulari, Elvira Smeralda& Fagoonee, Sharmila& van Daalen, Saskia K. M.& Buttiglieri, S.& Revelli, Alberto…[et al.]. 2018. Characterization of Human Mesenchymal Stem Cells Isolated from the Testis. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213450
Modern Language Association (MLA)
De Chiara, Letizia…[et al.]. Characterization of Human Mesenchymal Stem Cells Isolated from the Testis. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213450
American Medical Association (AMA)
De Chiara, Letizia& Famulari, Elvira Smeralda& Fagoonee, Sharmila& van Daalen, Saskia K. M.& Buttiglieri, S.& Revelli, Alberto…[et al.]. Characterization of Human Mesenchymal Stem Cells Isolated from the Testis. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213450
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213450