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Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural StemProgenitor Cells
Joint Authors
Tang, Peifu
Zhang, Licheng
Deng, Junhao
Zhang, Yiling
Xie, Yong
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-04
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Spinal cord injury (SCI) is an intractable and worldwide difficult medical challenge with limited treatments.
Neural stem/progenitor cell (NS/PC) transplantation derived from fetal tissues or embryonic stem cells (ESCs) has demonstrated therapeutic effects via replacement of lost neurons and severed axons and creation of permissive microenvironment to promote repair of spinal cord and axon regeneration but causes ethnical concerns and immunological rejections as well.
Thus, the implementation of induced pluripotent stem cells (iPSCs), which can be generated from adult somatic cells and differentiated into NS/PCs, provides an effective alternation in the treatment of SCI.
However, as researches further deepen, there is accumulating evidence that the use of iPSC-derived NS/PCs shows mounting concerns of safety, especially the tumorigenicity.
This review discusses the tumorigenicity of iPSC-derived NS/PCs focusing on the two different routes of tumorigenicity (teratomas and true tumors) and underlying mechanisms behind them, as well as possible solutions to circumvent them.
American Psychological Association (APA)
Deng, Junhao& Zhang, Yiling& Xie, Yong& Zhang, Licheng& Tang, Peifu. 2018. Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural StemProgenitor Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213477
Modern Language Association (MLA)
Deng, Junhao…[et al.]. Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural StemProgenitor Cells. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213477
American Medical Association (AMA)
Deng, Junhao& Zhang, Yiling& Xie, Yong& Zhang, Licheng& Tang, Peifu. Cell Transplantation for Spinal Cord Injury: Tumorigenicity of Induced Pluripotent Stem Cell-Derived Neural StemProgenitor Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213477
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213477