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Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation and Differentiation towards a Neuronal Fate
Joint Authors
Chung, Tae Nyoung
Moon, Mi-Young
Kim, Hyun Jung
Sohn, Min
Suh, Sang Won
Choi, Bo Young
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-18
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Zinc is an essential element required for cell division, migration, and proliferation.
Under zinc-deficient conditions, proliferation and differentiation of neural progenitors are significantly impaired.
Adipose-derived mesenchymal stem cells (AD-MSCs) are multipotent stem cells that can differentiate into neurons.
The aim of this study was to evaluate the effect of zinc on AD-MSC proliferation and differentiation.
We initially examined the effect of zinc on stem cell proliferation at the undifferentiated stage.
AD-MSCs showed high proliferation rates on day 6 in 30 μM and 100 μM of ZnCl2.
Zinc chelation inhibited AD-MSC proliferation via downregulation of ERK1/2 activity.
We then assessed whether zinc was involved in cell migration and neurite outgrowth during differentiation.
After three days of neuronal differentiation, TUJ-1-positive cells were observed, implying that AD-MSCs had differentiated into early neuron or neuron-like cells.
Neurite outgrowth was increased in the zinc-treated group, while the CaEDTA-treated group showed diminished, shrunken neurites.
Furthermore, we showed that zinc promoted neurite outgrowth via the inactivation of RhoA and led to the induction of neuronal gene expression (MAP2 and nestin) in differentiated stem cells.
Taken together, zinc promoted AD-MSC proliferation and affected neuronal differentiation, mainly by increasing neurite outgrowth.
American Psychological Association (APA)
Moon, Mi-Young& Kim, Hyun Jung& Choi, Bo Young& Sohn, Min& Chung, Tae Nyoung& Suh, Sang Won. 2018. Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation and Differentiation towards a Neuronal Fate. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213481
Modern Language Association (MLA)
Moon, Mi-Young…[et al.]. Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation and Differentiation towards a Neuronal Fate. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213481
American Medical Association (AMA)
Moon, Mi-Young& Kim, Hyun Jung& Choi, Bo Young& Sohn, Min& Chung, Tae Nyoung& Suh, Sang Won. Zinc Promotes Adipose-Derived Mesenchymal Stem Cell Proliferation and Differentiation towards a Neuronal Fate. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213481
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213481