Radiation Induces Apoptosis and Osteogenic Impairment through miR-22-Mediated Intracellular Oxidative Stress in Bone Marrow Mesenchymal Stem Cells
Joint Authors
Liu, Zhonglong
Li, Tao
Deng, Si’nan
Fu, Shuiting
Zhou, Xiaojun
He, Yue
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-12
Country of Publication
Egypt
No. of Pages
16
Abstract EN
Bone marrow mesenchymal stem cells (BMSCs) were characterized by their multilineage potential and were involved in both bony and soft tissue repair.
Exposure of cells to ionizing radiation (IR) triggers numerous biological reactions, including reactive oxygen species (ROS), cellular apoptosis, and impaired differentiation capacity, while the mechanisms of IR-induced BMSC apoptosis and osteogenic impairment are still unclear.
Through a recent study, we found that 6 Gy IR significantly increased the apoptotic ratio and ROS generation, characterized by ROS staining and mean fluorescent intensity.
Intervention with antioxidant (NAC) indicated that IR-induced cellular apoptosis was partly due to the accumulation of intracellular ROS.
Furthermore, we found that the upregulation of miR-22 in rBMSCs following 6 Gy IR played an important role on the ROS generation and subsequent apoptosis.
In addition, we firstly demonstrated that miR-22-mediated ROS accumulation and cell injury had an important regulated role on the osteogenic capacity of BMSCs both in vitro and in vivo.
In conclusion, IR-induced overexpression of miR-22 regulated the cell viability and differentiation potential through targeting the intracellular ROS.
American Psychological Association (APA)
Liu, Zhonglong& Li, Tao& Deng, Si’nan& Fu, Shuiting& Zhou, Xiaojun& He, Yue. 2018. Radiation Induces Apoptosis and Osteogenic Impairment through miR-22-Mediated Intracellular Oxidative Stress in Bone Marrow Mesenchymal Stem Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213485
Modern Language Association (MLA)
Liu, Zhonglong…[et al.]. Radiation Induces Apoptosis and Osteogenic Impairment through miR-22-Mediated Intracellular Oxidative Stress in Bone Marrow Mesenchymal Stem Cells. Stem Cells International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1213485
American Medical Association (AMA)
Liu, Zhonglong& Li, Tao& Deng, Si’nan& Fu, Shuiting& Zhou, Xiaojun& He, Yue. Radiation Induces Apoptosis and Osteogenic Impairment through miR-22-Mediated Intracellular Oxidative Stress in Bone Marrow Mesenchymal Stem Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213485
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213485