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Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease
Joint Authors
Park, Young-Seok
Kwak, Kyeong-Ah
Yang, Jin-Young
Lee, Seung-Pyo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-01
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Alzheimer’s disease (AD), a progressive neurodegenerative disorder featuring memory loss and cognitive impairment, is caused by synaptic failure and the excessive accumulation of misfolded proteins.
Many unsuccessful attempts have been made to develop new small molecules or antibodies to intervene in the disease’s pathogenesis.
Stem cell-based therapies cast a new hope for AD treatment as a replacement or regeneration strategy.
The results from recent preclinical studies regarding stem cell-based therapies are promising.
Human clinical trials are now underway.
However, a number of questions remain to be answered prior to safe and effective clinical translation.
This review explores the pathophysiology of AD and summarizes the relevant stem cell research according to cell type.
We also briefly summarize related clinical trials.
Finally, future perspectives are discussed with regard to their clinical applications.
American Psychological Association (APA)
Kwak, Kyeong-Ah& Lee, Seung-Pyo& Yang, Jin-Young& Park, Young-Seok. 2018. Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease. Stem Cells International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213515
Modern Language Association (MLA)
Kwak, Kyeong-Ah…[et al.]. Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease. Stem Cells International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1213515
American Medical Association (AMA)
Kwak, Kyeong-Ah& Lee, Seung-Pyo& Yang, Jin-Young& Park, Young-Seok. Current Perspectives regarding Stem Cell-Based Therapy for Alzheimer’s Disease. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213515
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213515