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Recovery of Donor Hematopoiesis after Graft Failure and Second Hematopoietic Stem Cell Transplantation with Intraosseous Administration of Mesenchymal Stromal Cells
Joint Authors
Kuzmina, Larisa A.
Petinati, Natalia A.
Parovichnikova, Elena N.
Drize, Nina J.
Savchenko, Valery G.
Sats, Natalia
Risinskaya, Natalya
Sudarikov, Andrey
Drokov, Michail
Dubniak, Daria
Kraizman, Alina
Nareyko, Maria
Popova, Natalia
Firsova, Maya
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-10
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Multipotent mesenchymal stromal cells (MSCs) participate in the formation of bone marrow niches for hematopoietic stem cells.
Donor MSCs can serve as a source of recovery for niches in patients with graft failure (GF) after allogeneic bone marrow (BM) transplantation.
Since only few MSCs reach the BM after intravenous injection, MSCs were implanted into the iliac spine.
For 8 patients with GF after allo-BMT, another hematopoietic stem cell transplantation with simultaneous implantation of MSCs from their respective donors into cancellous bone was performed.
BM was aspirated from the iliac crest of these patients at 1-2, 4-5, and 9 months after the intraosseous injection of donor MSCs.
Patients’ MSCs were cultivated, and chimerism was determined.
In 6 out of 8 patients, donor hematopoiesis was restored.
Donor cells (9.4 ± 3.3%) were detected among MSCs.
Thus, implanted MSCs remain localized at the site of administration and do not lose the ability to proliferate.
These results suggest that MSCs could participate in the restoration of niches for donor hematopoietic cells or have an immunomodulatory effect, preventing repeated rejection of the graft.
Perhaps, intraosseous implantation of MSCs contributes to the success of the second transplantation of hematopoietic stem cells and patient survival.
American Psychological Association (APA)
Petinati, Natalia A.& Drize, Nina J.& Sats, Natalia& Risinskaya, Natalya& Sudarikov, Andrey& Drokov, Michail…[et al.]. 2018. Recovery of Donor Hematopoiesis after Graft Failure and Second Hematopoietic Stem Cell Transplantation with Intraosseous Administration of Mesenchymal Stromal Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213519
Modern Language Association (MLA)
Petinati, Natalia A.…[et al.]. Recovery of Donor Hematopoiesis after Graft Failure and Second Hematopoietic Stem Cell Transplantation with Intraosseous Administration of Mesenchymal Stromal Cells. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213519
American Medical Association (AMA)
Petinati, Natalia A.& Drize, Nina J.& Sats, Natalia& Risinskaya, Natalya& Sudarikov, Andrey& Drokov, Michail…[et al.]. Recovery of Donor Hematopoiesis after Graft Failure and Second Hematopoietic Stem Cell Transplantation with Intraosseous Administration of Mesenchymal Stromal Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213519
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213519