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Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement
Joint Authors
Zhou, Yanheng
Huang, Huaming
Yang, Ruili
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-17
Country of Publication
Egypt
No. of Pages
7
Abstract EN
Periodontal ligament stem cells (PDLSCs) possess self-renewal, multilineage differentiation, and immunomodulatory properties.
They play a crucial role in maintaining periodontal homeostasis and also participated in orthodontic tooth movement (OTM).
Various studies have applied controlled mechanical stimulation to PDLSCs and investigated the effects of orthodontic force on PDLSCs.
Physical stimuli can regulate the proliferation and differentiation of PDLSCs.
During the past decade, a variety of studies has demonstrated that applied forces can activate different signaling pathways in PDLSCs, including MAPK, TGF-β/Smad, and Wnt/β-catenin pathways.
Besides, recent advances have highlighted the critical role of orthodontic force in PDLSC fate through mediators, such as IL-11, CTHRC1, miR-21, and H2S.
This perspective review critically discusses the PDLSC fate to physical force in vitro and orthodontic force in vivo, as well as the underlying molecular mechanism involved in OTM.
American Psychological Association (APA)
Huang, Huaming& Yang, Ruili& Zhou, Yanheng. 2018. Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement. Stem Cells International،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213520
Modern Language Association (MLA)
Huang, Huaming…[et al.]. Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement. Stem Cells International No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1213520
American Medical Association (AMA)
Huang, Huaming& Yang, Ruili& Zhou, Yanheng. Mechanobiology of Periodontal Ligament Stem Cells in Orthodontic Tooth Movement. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1213520
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213520