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Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction
Joint Authors
Zeng, Chunyu
Chen, Zhi
Chen, Long
Wang, Wei Eric
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-25
Country of Publication
Egypt
No. of Pages
14
Abstract EN
Myocardial infarction (MI) is one of the leading causes of death worldwide.
Mesenchymal stem cell (MSC) transplantation is considered a promising approach and has made significant progress in preclinical studies and clinical trials for treating MI.
However, hurdles including poor survival, retention, homing, and differentiation capacity largely limit the therapeutic effect of transplanted MSCs.
Many strategies such as preconditioning, genetic modification, cotransplantation with bioactive factors, and tissue engineering were developed to improve the survival and function of MSCs.
On the other hand, optimizing the hostile transplantation microenvironment of the host myocardium is also of importance.
Here, we review the modifications of MSCs as well as the host myocardium to improve the efficacy of MSC-based therapy against MI.
American Psychological Association (APA)
Chen, Zhi& Chen, Long& Zeng, Chunyu& Wang, Wei Eric. 2018. Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction. Stem Cells International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213535
Modern Language Association (MLA)
Chen, Zhi…[et al.]. Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction. Stem Cells International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1213535
American Medical Association (AMA)
Chen, Zhi& Chen, Long& Zeng, Chunyu& Wang, Wei Eric. Functionally Improved Mesenchymal Stem Cells to Better Treat Myocardial Infarction. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213535
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213535