Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study
Joint Authors
Sanchez-Guijo, Fermin
Blanco, Juan Francisco
García-Briñon, Jesús
Benito-Garzón, Lorena
Pescador, David
Muntión, Sandra
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Significant research efforts have been undertaken during the last decades to treat musculoskeletal disorders and improve patient’s mobility and quality of life.
The goal is the return of function as quickly and completely as possible.
Cellular therapy has been increasingly employed in this setting.
The design of this study was focused on cell-based alternatives.
The present study aimed at investigating the bone regeneration capacity of xenogeneic human bone marrow-derived mesenchymal stromal cell (hMSC) implantation with tricalcium phosphate (TCP) granules in an immunocompetent rabbit model of critical-size bone defects at the femoral condyles.
Two experimental groups, TCP and hMSC + TCP, were compared.
Combination of TCP and hMSC did not affect cell viability or osteogenic differentiation.
We also observed significantly higher bone regeneration in vivo in the hMSC + TCP group, which also displayed better TCP osteointegration.
Also, evidence of hMSC contribution to a better TCP osteointegration was noticed.
Finally, no inflammatory reaction was detected, besides the xenotransplantation of human cells into an immunocompetent recipient.
In summary, hMSC combined with TCP granules is a potential combination for bone regeneration purposes that provides better preclinical results compared to TCP alone.
American Psychological Association (APA)
Blanco, Juan Francisco& García-Briñon, Jesús& Benito-Garzón, Lorena& Pescador, David& Muntión, Sandra& Sanchez-Guijo, Fermin. 2018. Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213539
Modern Language Association (MLA)
Blanco, Juan Francisco…[et al.]. Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213539
American Medical Association (AMA)
Blanco, Juan Francisco& García-Briñon, Jesús& Benito-Garzón, Lorena& Pescador, David& Muntión, Sandra& Sanchez-Guijo, Fermin. Human Bone Marrow Mesenchymal Stromal Cells Promote Bone Regeneration in a Xenogeneic Rabbit Model: A Preclinical Study. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213539
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213539