Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro
Joint Authors
Abomaray, F. M.
Götherström, Cecilia
Gidlöf, Sebastian
Bezubik, Bartosz
Engman, Mikael
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-28
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Endometriosis is an inflammatory disease marked by ectopic growth of endometrial cells.
Mesenchymal stromal cells (MSC) have immunosuppressive properties that have been suggested as a treatment for inflammatory diseases.
Therefore, the aim herein was to examine effects of allogeneic MSC on endometriosis-derived cells in vitro as a potential therapy for endometriosis.
MSC from allogeneic adipose tissue (Ad-MSC) and stromal cells from endometrium (ESCendo) and endometriotic ovarian cysts (ESCcyst) from women with endometriosis were isolated.
The effects of Ad-MSC on ESCendo and ESCcyst were investigated using in vitro proliferation, apoptosis, adhesion, tube formation, migration, and invasion assays.
Ad-MSC significantly increased proliferation of ESC compared to untreated controls.
Moreover, Ad-MSC significantly decreased apoptosis and increased survival of ESC.
Ad-MSC significantly increased adhesion of ESCendo and not ESCcyst on fibronectin.
Conditioned medium from cocultures of Ad-MSC and ESC significantly increased tube formation of human umbilical vein endothelial cells on matrigel.
Ad-MSC may significantly increase migration of ESCcyst and did not increase invasion of both cell types.
The data suggest that allogeneic Ad-MSC should not be considered as a potential therapy for endometriosis, because they may support the pathology by maintaining and increasing growth of ectopic endometrial tissue.
American Psychological Association (APA)
Abomaray, F. M.& Gidlöf, Sebastian& Bezubik, Bartosz& Engman, Mikael& Götherström, Cecilia. 2018. Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213557
Modern Language Association (MLA)
Abomaray, F. M.…[et al.]. Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213557
American Medical Association (AMA)
Abomaray, F. M.& Gidlöf, Sebastian& Bezubik, Bartosz& Engman, Mikael& Götherström, Cecilia. Mesenchymal Stromal Cells Support Endometriotic Stromal Cells In Vitro. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213557
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213557