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MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells
Joint Authors
Tang, Yaoliang
Shui, Xiaorong
Lei, Wei
Lan, Xiaozhong
He, Yuan
Chen, Can
Yan, Quanxiang
Yan, Yiguang
Ma, Mudi
Yang, Zhigang
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-05
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Stem cell transplantation is one of most valuable methods in the treatment of myocardial infarction, and adipose-derived stem cells (ASCs) are becoming a hot topic in medical research.
Previous studies have shown that ASCs can be differentiated into cardiomyocyte-like cells, but the efficiency and survival rates are low.
We investigated the role and mechanism of microRNA-1 (miR-1) in the differentiation of ASCs into cardiomyocyte-like cells.
ASCs and cardiomyocytes were isolated from neonatal rats.
We constructed lentivirus for overexpressing miR-1 and used DAPT, an antagonist of the Notch1 pathway, for in vitro analyses.
We performed cocultures with ASCs and cardiomyocytes.
The differentiation efficiency of ASCs was detected by cell-specific surface antigens.
Our results showed that miR-1 can promote the expression of Notch1 and reduce the expression of Hes1, a Notch pathway factor, and overexpression of miR-1 can promote the differentiation of ASCs into cardiomyocyte-like cells, which may occur by regulating Notch1 and Hes1.
American Psychological Association (APA)
Chen, Can& Yan, Quanxiang& Yan, Yiguang& Ma, Mudi& He, Yuan& Shui, Xiaorong…[et al.]. 2018. MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213567
Modern Language Association (MLA)
Chen, Can…[et al.]. MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells. Stem Cells International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1213567
American Medical Association (AMA)
Chen, Can& Yan, Quanxiang& Yan, Yiguang& Ma, Mudi& He, Yuan& Shui, Xiaorong…[et al.]. MicroRNA-1 Regulates the Differentiation of Adipose-Derived Stem Cells into Cardiomyocyte-Like Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213567
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213567