Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials
Joint Authors
Xie, Baocheng
Xu, Daohua
Wang, Qinghui
Zhou, Chenhui
Luo, Houlong
Zhang, Yusheng
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-24
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Objective.
Critical limb ischemia (CLI) is the most dangerous stage of peripheral artery disease (PAD).
Many basic researches and clinical treatment had been focused on stem cell transplantation for CLI.
This systematic review was performed to review evidence for safety and efficacy of autologous stem cell therapy in CLI.
Methods.
A systematic literature search was performed in the SinoMed, PubMed, Embase, ClinicalTrials.gov, and Cochrane Controlled Trials Register databases from building database to January 2018.
Results.
Meta-analysis showed that cell therapy significantly increased the probability of ulcer healing (RR = 1.73, 95% CI = 1.45–2.06), angiogenesis (RR = 5.91, 95% CI = 2.49–14.02), and reduced the amputation rates (RR = 0.59, 95% CI = 0.46–0.76).
Ankle-brachial index (ABI) (MD = 0.13, 95% CI = 0.11–0.15), TcO2 (MD = 12.22, 95% CI = 5.03–19.41), and pain-free walking distance (MD = 144.84, 95% CI = 53.03–236.66) were significantly better in the cell therapy group than in the control group (P<0.01).
Conclusions.
The results of this meta-analysis indicate that autologous stem cell therapy is safe and effective in CLI.
However, higher quality and larger RCTs are required for further investigation to support clinical application of stem cell transplantation.
American Psychological Association (APA)
Xie, Baocheng& Luo, Houlong& Zhang, Yusheng& Wang, Qinghui& Zhou, Chenhui& Xu, Daohua. 2018. Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213568
Modern Language Association (MLA)
Xie, Baocheng…[et al.]. Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213568
American Medical Association (AMA)
Xie, Baocheng& Luo, Houlong& Zhang, Yusheng& Wang, Qinghui& Zhou, Chenhui& Xu, Daohua. Autologous Stem Cell Therapy in Critical Limb Ischemia: A Meta-Analysis of Randomized Controlled Trials. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213568
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213568