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Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction
Joint Authors
Kjaer, Andreas
Kastrup, Jens
Haack-Sørensen, Mandana
Ekblond, Annette
Lund, Lisbeth Drozd
Follin, Bjarke
Ghotbi, Adam Ali
Clemmensen, Andreas Ettrup
Bentsen, Simon
Juhl, Morten
Søndergaard, Rebekka Harary
Hasbak, Philip
Cohen, Smadar
Ripa, Rasmus Sejersten
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-26
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Background.
Cell therapy for heart disease has been proven safe and efficacious, despite poor cell retention in the injected area.
Improving cell retention is hypothesized to increase the treatment effect.
In the present study, human adipose-derived stromal cells (ASCs) were delivered in an in situ forming alginate hydrogel following acute myocardial infarction (AMI) in rats.
Methods.
ASCs were transduced with luciferase and tested for ASC phenotype.
AMI was inducted in nude rats, with subsequent injection of saline (controls), 1 × 106 ASCs in saline or 1 × 106 ASCs in 1% (w/v) alginate hydrogel.
ASCs were tracked by bioluminescence and functional measurements were assessed by magnetic resonance imaging (MRI) and 82rubidium positron emission tomography (PET).
Results.
ASCs in both saline and alginate hydrogel significantly increased the ejection fraction (7.2% and 7.8% at 14 days and 7.2% and 8.0% at 28 days, resp.).
After 28 days, there was a tendency for decreased infarct area and increased perfusion, compared to controls.
No significant differences were observed between ASCs in saline or alginate hydrogel, in terms of retention and functional salvage.
Conclusion.
ASCs improved the myocardial function after AMI, but administration in the alginate hydrogel did not further improve retention of the cells or myocardial function.
American Psychological Association (APA)
Follin, Bjarke& Ghotbi, Adam Ali& Clemmensen, Andreas Ettrup& Bentsen, Simon& Juhl, Morten& Søndergaard, Rebekka Harary…[et al.]. 2018. Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction. Stem Cells International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213580
Modern Language Association (MLA)
Follin, Bjarke…[et al.]. Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction. Stem Cells International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1213580
American Medical Association (AMA)
Follin, Bjarke& Ghotbi, Adam Ali& Clemmensen, Andreas Ettrup& Bentsen, Simon& Juhl, Morten& Søndergaard, Rebekka Harary…[et al.]. Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213580
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213580