Mesenchymal StromalStem Cells in Regenerative Medicine and Tissue Engineering
Joint Authors
Fitzsimmons, Ross E. B.
Mazurek, Matthew S.
Soos, Agnes
Simmons, Craig A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-19
Country of Publication
Egypt
No. of Pages
16
Abstract EN
As a result of over five decades of investigation, mesenchymal stromal/stem cells (MSCs) have emerged as a versatile and frequently utilized cell source in the fields of regenerative medicine and tissue engineering.
In this review, we summarize the history of MSC research from the initial discovery of their multipotency to the more recent recognition of their perivascular identity in vivo and their extraordinary capacity for immunomodulation and angiogenic signaling.
As well, we discuss long-standing questions regarding their developmental origins and their capacity for differentiation toward a range of cell lineages.
We also highlight important considerations and potential risks involved with their isolation, ex vivo expansion, and clinical use.
Overall, this review aims to serve as an overview of the breadth of research that has demonstrated the utility of MSCs in a wide range of clinical contexts and continues to unravel the mechanisms by which these cells exert their therapeutic effects.
American Psychological Association (APA)
Fitzsimmons, Ross E. B.& Mazurek, Matthew S.& Soos, Agnes& Simmons, Craig A.. 2018. Mesenchymal StromalStem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells International،Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213589
Modern Language Association (MLA)
Fitzsimmons, Ross E. B.…[et al.]. Mesenchymal StromalStem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells International No. 2018 (2018), pp.1-16.
https://search.emarefa.net/detail/BIM-1213589
American Medical Association (AMA)
Fitzsimmons, Ross E. B.& Mazurek, Matthew S.& Soos, Agnes& Simmons, Craig A.. Mesenchymal StromalStem Cells in Regenerative Medicine and Tissue Engineering. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-16.
https://search.emarefa.net/detail/BIM-1213589
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213589