Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets
Joint Authors
Chen, Bin
Zhang, Yangheng
Ni, Yanhong
Liu, Jiaying
Yan, Fuhua
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-24
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Mesenchymal stem cells (MSCs) and their secreted molecules have shown great potential for tissue regeneration and the treatment of inflammation and autoimmune diseases.
However, they can also be associated with therapeutic failure or even side effects.
Possible causes for this could include the state of the stem cells themselves and the influence of the local microenvironment, wherein macrophages play important roles.
As such, we utilized conditioned medium from bone marrow-derived MSCs (MSC-CM) and studied its effect on different macrophage subsets.
Effects on macrophage proliferation, apoptosis, polarization, and phagocytosis were determined, and it was discovered that MSC-CM had no significant effect on macrophage proliferation but inhibited M0 macrophage apoptosis and marginally induced M1 macrophage apoptosis.
MSC-CM was shown to reduce CD80 expression on the surface of M1 macrophages.
Moreover, it promoted and inhibited CD163 expression on the surface of M0 and M1 macrophages, respectively.
However, MSC-CM tended to initially promote CD163 expression on M2 macrophages but inhibited expression of this marker after additional incubation time.
Unlike MSCs, MSC-CM had no significant effect on the expression of TNF-α and IL-10 in macrophages.
Thus, the effect of MSC-CM on different types of macrophages is different, and after stem cells are implanted, their effects on the local immune microenvironment are closely related to the original immune status of the implantation site.
Therefore, we suggest that when utilizing stem cells for therapeutics, the immune status of the treatment site should be fully elucidated.
American Psychological Association (APA)
Chen, Bin& Ni, Yanhong& Liu, Jiaying& Zhang, Yangheng& Yan, Fuhua. 2018. Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213601
Modern Language Association (MLA)
Chen, Bin…[et al.]. Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213601
American Medical Association (AMA)
Chen, Bin& Ni, Yanhong& Liu, Jiaying& Zhang, Yangheng& Yan, Fuhua. Bone Marrow-Derived Mesenchymal Stem Cells Exert Diverse Effects on Different Macrophage Subsets. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213601
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213601