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SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-10
Country of Publication
Egypt
No. of Pages
10
Abstract EN
Stem cells, including embryonic stem cells (ESCs) and adult stem cells, play a central role in mammal organism development and homeostasis.
They have two unique properties: the capacity for self-renewal and the ability to differentiate into many specialized cell types.
Src homology region 2- (SH2-) containing protein tyrosine phosphatase 2 (SHP-2), a nonreceptor protein tyrosine phosphatase encoded by protein tyrosine phosphatase nonreceptor type 11 gene (PTPN11), regulates multicellular differentiation, proliferation, and survival through numerous conserved signal pathways.
Gain-of-function (GOF) or loss-of-function (LOF) SHP2 in various cells, especially for stem cells, disrupt organism self-balance and lead to a plethora of diseases, such as cancer, maldevelopment, and excessive hyperblastosis.
However, the exact mechanisms of SHP2 dysfunction in stem cells remain unclear.
In this review, we intended to raise the attention and clarify the framework of SHP2-mediated signal pathways in various stem cells.
Establishment of integrated signal architecture, from ESCs to adult stem cells, will help us to understand the changes of dynamic, multilayered pathways in response to SHP2 dysfunction.
Overall, better understanding the functions of SHP2 in stem cells provides a new avenue to treat SHP2-associated diseases.
American Psychological Association (APA)
Kan, Chen& Yang, Fan& Wang, Si Y.. 2018. SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction. Stem Cells International،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213602
Modern Language Association (MLA)
Kan, Chen…[et al.]. SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction. Stem Cells International No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1213602
American Medical Association (AMA)
Kan, Chen& Yang, Fan& Wang, Si Y.. SHP2-Mediated Signal Networks in Stem Cell Homeostasis and Dysfunction. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1213602
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213602