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Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue
Joint Authors
Kim, Jin-Hee
Jo, Chris H.
Kim, Hang-Rae
Hwang, Young-il
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-01
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Mesenchymal stem cells (MSCs) are of therapeutic importance in the fields of regenerative medicine and immunological diseases.
Accordingly, studies evaluating MSCs for clinical applications are increasing.
In this study, we characterized MSCs from the periodontal ligament, umbilical cord (UC-MSCs), and adipose tissue, which were relatively easy to obtain with limited ethical concerns regarding their acquisition, and compared their immunological characteristics.
Among MSCs isolated from the three different tissues, UC-MSCs grew the fastest in vitro.
The three types of MSCs were shown to inhibit proliferation of activated peripheral blood mononuclear cells (PBMCs) to a similar degree, via the indoleamine 2,3-dioxygenase and cyclooxygenase-2 pathways.
They were also shown to inhibit the proliferation of PBMCs using HLA-G, which was most prominent in UC-MSCs.
Unlike the other two types of MSCs, UC-MSCs showed minimal expression of HLA-DR after activation, suggesting that they pose minimal risk of initiating an allogeneic immune response when administered in vivo.
These characteristics, the ease of collection, and the minimal ethical concerns regarding their use suggest UC-MSCs to be suitable MSC therapeutic candidates.
American Psychological Association (APA)
Kim, Jin-Hee& Jo, Chris H.& Kim, Hang-Rae& Hwang, Young-il. 2018. Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213603
Modern Language Association (MLA)
Kim, Jin-Hee…[et al.]. Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213603
American Medical Association (AMA)
Kim, Jin-Hee& Jo, Chris H.& Kim, Hang-Rae& Hwang, Young-il. Comparison of Immunological Characteristics of Mesenchymal Stem Cells from the Periodontal Ligament, Umbilical Cord, and Adipose Tissue. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213603
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213603