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Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration
Joint Authors
Ju, Ji Hyeon
Lee, Jennifer
Rim, Yeri Alice
Nam, Yoojun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-20, 20 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-03-25
Country of Publication
Egypt
No. of Pages
20
Abstract EN
The process of cartilage destruction in the diarthrodial joint is progressive and irreversible.
This destruction is extremely difficult to manage and frustrates researchers, clinicians, and patients.
Patients often take medication to control their pain.
Surgery is usually performed when pain becomes uncontrollable or joint function completely fails.
There is an unmet clinical need for a regenerative strategy to treat cartilage defect without surgery due to the lack of a suitable regenerative strategy.
Clinicians and scientists have tried to address this using stem cells, which have a regenerative potential in various tissues.
Cartilage may be an ideal target for stem cell treatment because it has a notoriously poor regenerative potential.
In this review, we describe past, present, and future strategies to regenerate cartilage in patients.
Specifically, this review compares a surgical regenerative technique (microfracture) and cell therapy, cell therapy with and without a scaffold, and therapy with nonaggregated and aggregated cells.
We also review the chondrogenic potential of cells according to their origin, including autologous chondrocytes, mesenchymal stem cells, and induced pluripotent stem cells.
American Psychological Association (APA)
Nam, Yoojun& Rim, Yeri Alice& Lee, Jennifer& Ju, Ji Hyeon. 2018. Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration. Stem Cells International،Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1213606
Modern Language Association (MLA)
Nam, Yoojun…[et al.]. Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration. Stem Cells International No. 2018 (2018), pp.1-20.
https://search.emarefa.net/detail/BIM-1213606
American Medical Association (AMA)
Nam, Yoojun& Rim, Yeri Alice& Lee, Jennifer& Ju, Ji Hyeon. Current Therapeutic Strategies for Stem Cell-Based Cartilage Regeneration. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-20.
https://search.emarefa.net/detail/BIM-1213606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213606