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Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity
Joint Authors
Du, Guizhen
Yu, Mingming
Wang, Lingling
Hu, Weiyue
Song, Ling
Lu, Chuncheng
Wang, Xinru
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-29
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Cardiac development is a dynamic process and sensitive to environmental chemicals.
Triclosan is widely used as an antibacterial agent and reported to transport across the placenta and affect embryonic development.
Here, we used human embryonic stem cell- (hESC-) derived cardiomyocytes (CMs) to determine the effects of TCS exposure on cardiac development.
After TCS treatment, the differentiation process was significantly blocked and spontaneous beating rates of CMs were also decreased.
Transcriptome analysis showed the dysregulation of genes involved in cardiogenesis, including GATA4 and TNNT2.
Additionally, DNA methylation was also altered by TCS exposure, especially in those regions with GATA motif enrichment.
These alterations of transcriptome and DNA methylation were all associated with signaling pathways integral to heart development.
Our findings indicate that TCS exposure might cause cardiomyocyte differentiation toxicity and provide the new insights into how environmental factors regulate DNA methylation and gene expressions during heart development.
American Psychological Association (APA)
Du, Guizhen& Yu, Mingming& Wang, Lingling& Hu, Weiyue& Song, Ling& Lu, Chuncheng…[et al.]. 2018. Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1213609
Modern Language Association (MLA)
Du, Guizhen…[et al.]. Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1213609
American Medical Association (AMA)
Du, Guizhen& Yu, Mingming& Wang, Lingling& Hu, Weiyue& Song, Ling& Lu, Chuncheng…[et al.]. Transcriptome and DNA Methylome Dynamics during Triclosan-Induced Cardiomyocyte Differentiation Toxicity. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1213609
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213609