![](/images/graphics-bg.png)
Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity
Joint Authors
Tsuji, Kenji
Wada, Jun
Kitamura, Shinji
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-16
Country of Publication
Egypt
No. of Pages
14
Abstract EN
A kidney has the ability to regenerate itself after a variety of renal injuries.
Mesenchymal stem cells (MSCs) have been shown to ameliorate tissue damages during renal injuries and diseases.
The regenerations induced by MSCs are primarily mediated by the paracrine release of soluble factors and extracellular vesicles, including exosomes and microvesicles.
Extracellular vesicles contain proteins, microRNAs, and mRNAs that are transferred into recipient cells to induce several repair signaling pathways.
Over the past few decades, many studies identified trophic factors from MSCs, which attenuate renal injury in a variety of animal acute kidney injury models, including renal ischemia-reperfusion injury and drug-induced renal injury, using microarray and proteomic analysis.
Nevertheless, these studies have revealed the heterogeneity of trophic factors from MSCs that depend on the cell origins and different stimuli including hypoxia, inflammatory stimuli, and aging.
In this review article, we summarize the secretomes and regenerative mechanisms induced by MSCs and highlight the possible heterogeneity of trophic factors from different types of MSC and different circumstances for renal regeneration.
American Psychological Association (APA)
Tsuji, Kenji& Kitamura, Shinji& Wada, Jun. 2018. Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity. Stem Cells International،Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213615
Modern Language Association (MLA)
Tsuji, Kenji…[et al.]. Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity. Stem Cells International No. 2018 (2018), pp.1-14.
https://search.emarefa.net/detail/BIM-1213615
American Medical Association (AMA)
Tsuji, Kenji& Kitamura, Shinji& Wada, Jun. Secretomes from Mesenchymal Stem Cells against Acute Kidney Injury: Possible Heterogeneity. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-14.
https://search.emarefa.net/detail/BIM-1213615
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213615