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Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate
Joint Authors
Bertucci, Taylor B.
Dai, Guohao
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-05
Country of Publication
Egypt
No. of Pages
12
Abstract EN
Pluripotent stem cells (PSCs) represent an exciting cell source for tissue engineering and regenerative medicine due to their self-renewal and differentiation capacities.
The majority of current PSC protocols rely on 2D cultures and soluble factors to guide differentiation; however, many other environmental signals are beginning to be explored using biomaterial platforms.
Biomaterials offer new opportunities to engineer the stem cell niches and 3D environments for exploring biophysical and immobilized signaling cues to further our control over stem cell fate.
Here, we review the biomaterial platforms that have been engineered to control PSC fate.
We explore how altering immobilized biochemical cues and biophysical cues such as dimensionality, stiffness, and topography can enhance our control over stem cell fates.
Finally, we highlight biomaterial culture systems that assist in the translation of PSC technologies for clinical applications.
American Psychological Association (APA)
Bertucci, Taylor B.& Dai, Guohao. 2018. Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate. Stem Cells International،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213633
Modern Language Association (MLA)
Bertucci, Taylor B.& Dai, Guohao. Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate. Stem Cells International No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1213633
American Medical Association (AMA)
Bertucci, Taylor B.& Dai, Guohao. Biomaterial Engineering for Controlling Pluripotent Stem Cell Fate. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1213633
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213633