Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures
Joint Authors
Ratajczak, Jessica
Bronckaers, Annelies
Gervois, Pascal
Hilkens, Petra
Merckx, Greet
Lo Monaco, Melissa
Clegg, Peter
Vandeweerd, Jean-Michel
Lambrichts, Ivo
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-22, 22 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-05
Country of Publication
Egypt
No. of Pages
22
Abstract EN
Due to the restricted intrinsic capacity of resident chondrocytes to regenerate the lost cartilage postinjury, stem cell-based therapies have been proposed as a novel therapeutic approach for cartilage repair.
Moreover, stem cell-based therapies using mesenchymal stem cells (MSCs) or induced pluripotent stem cells (iPSCs) have been used successfully in preclinical and clinical settings.
Despite these promising reports, the exact mechanisms underlying stem cell-mediated cartilage repair remain uncertain.
Stem cells can contribute to cartilage repair via chondrogenic differentiation, via immunomodulation, or by the production of paracrine factors and extracellular vesicles.
But before novel cell-based therapies for cartilage repair can be introduced into the clinic, rigorous testing in preclinical animal models is required.
Preclinical models used in regenerative cartilage studies include murine, lapine, caprine, ovine, porcine, canine, and equine models, each associated with its specific advantages and limitations.
This review presents a summary of recent in vitro data and from in vivo preclinical studies justifying the use of MSCs and iPSCs in cartilage tissue engineering.
Moreover, the advantages and disadvantages of utilizing small and large animals will be discussed, while also describing suitable outcome measures for evaluating cartilage repair.
American Psychological Association (APA)
Lo Monaco, Melissa& Merckx, Greet& Ratajczak, Jessica& Gervois, Pascal& Hilkens, Petra& Clegg, Peter…[et al.]. 2018. Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures. Stem Cells International،Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1213634
Modern Language Association (MLA)
Lo Monaco, Melissa…[et al.]. Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures. Stem Cells International No. 2018 (2018), pp.1-22.
https://search.emarefa.net/detail/BIM-1213634
American Medical Association (AMA)
Lo Monaco, Melissa& Merckx, Greet& Ratajczak, Jessica& Gervois, Pascal& Hilkens, Petra& Clegg, Peter…[et al.]. Stem Cells for Cartilage Repair: Preclinical Studies and Insights in Translational Animal Models and Outcome Measures. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-22.
https://search.emarefa.net/detail/BIM-1213634
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213634