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Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics
Joint Authors
Sen, Arindom
Ungrin, Mark
Sanati-Nezhad, Amir
Phelps, Jolene
Duncan, Neil A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-12
Country of Publication
Egypt
No. of Pages
23
Abstract EN
Mesenchymal stem cells (MSCs) have attracted tremendous research interest due to their ability to repair tissues and reduce inflammation when implanted into a damaged or diseased site.
These therapeutic effects have been largely attributed to the collection of biomolecules they secrete (i.e., their secretome).
Recent studies have provided evidence that similar effects may be produced by utilizing only the secretome fraction containing extracellular vesicles (EVs).
EVs are cell-derived, membrane-bound vesicles that contain various biomolecules.
Due to their small size and relative mobility, they provide a stable mechanism to deliver biomolecules (i.e., biological signals) throughout an organism.
The use of the MSC secretome, or its components, has advantages over the implantation of the MSCs themselves: (i) signals can be bioengineered and scaled to specific dosages, and (ii) the nonliving nature of the secretome enables it to be efficiently stored and transported.
However, since the composition and therapeutic benefit of the secretome can be influenced by cell source, culture conditions, isolation methods, and storage conditions, there is a need for standardization of bioprocessing parameters.
This review focuses on key parameters within the MSC culture environment that affect the nature and functionality of the secretome.
This information is pertinent to the development of bioprocesses aimed at scaling up the production of secretome-derived products for their use as therapeutics.
American Psychological Association (APA)
Phelps, Jolene& Sanati-Nezhad, Amir& Ungrin, Mark& Duncan, Neil A.& Sen, Arindom. 2018. Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics. Stem Cells International،Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1213668
Modern Language Association (MLA)
Phelps, Jolene…[et al.]. Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics. Stem Cells International No. 2018 (2018), pp.1-23.
https://search.emarefa.net/detail/BIM-1213668
American Medical Association (AMA)
Phelps, Jolene& Sanati-Nezhad, Amir& Ungrin, Mark& Duncan, Neil A.& Sen, Arindom. Bioprocessing of Mesenchymal Stem Cells and Their Derivatives: Toward Cell-Free Therapeutics. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-23.
https://search.emarefa.net/detail/BIM-1213668
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213668