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Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells
Joint Authors
Ju, Ji Hyeon
Lee, Jennifer
Rim, Yeri Alice
Park, Narae
Nam, Yoojun
Jung, Hyerin
Jang, Yeonsue
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-21
Country of Publication
Egypt
No. of Pages
13
Abstract EN
Scientists have tried to reprogram various origins of primary cells into human induced pluripotent stem cells (hiPSCs).
Every somatic cell can theoretically become a hiPSC and give rise to targeted cells of the human body.
However, there have been debates on the controversy about the differentiation propensity according to the origin of primary cells.
We reprogrammed hiPSCs from four different types of primary cells such as dermal fibroblasts (DF, n=3), peripheral blood mononuclear cells (PBMC, n=3), cord blood mononuclear cells (CBMC, n=3), and osteoarthritis fibroblast-like synoviocytes (OAFLS, n=3).
Established hiPSCs were differentiated into chondrogenic pellets.
All told, cartilage-specific markers tended to express more by the order of CBMC > DF > PBMC > FLS.
Origin of primary cells may influence the reprogramming and differentiation thereafter.
In the context of chondrogenic propensity, CBMC-derived hiPSCs can be a fairly good candidate cell source for cartilage regeneration.
The differentiation of hiPSCs into chondrocytes may help develop “cartilage in a dish” in the future.
Also, the ideal cell source of hiPSC for chondrogenesis may contribute to future application as well.
American Psychological Association (APA)
Rim, Yeri Alice& Nam, Yoojun& Park, Narae& Jung, Hyerin& Jang, Yeonsue& Lee, Jennifer…[et al.]. 2018. Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213670
Modern Language Association (MLA)
Rim, Yeri Alice…[et al.]. Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells. Stem Cells International No. 2018 (2018), pp.1-13.
https://search.emarefa.net/detail/BIM-1213670
American Medical Association (AMA)
Rim, Yeri Alice& Nam, Yoojun& Park, Narae& Jung, Hyerin& Jang, Yeonsue& Lee, Jennifer…[et al.]. Different Chondrogenic Potential among Human Induced Pluripotent Stem Cells from Diverse Origin Primary Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-13.
https://search.emarefa.net/detail/BIM-1213670
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213670