![](/images/graphics-bg.png)
Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells
Joint Authors
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-31
Country of Publication
Egypt
No. of Pages
8
Abstract EN
Mesenchymal stem cells (MSCs) are adult stem cells with fibroblast-like morphology and isolated from the bone marrow via plastic adhesion.
Their multipotency and immunoregulatory properties make MSCs possible therapeutic agents, and an increasing number of publications and clinical trials have highlighted their potential in regenerative medicine.
However, the finite proliferative capacity of MSCs limits their scalability and global dissemination as a standardized therapeutic product.
Furthermore, adult tissue provenance could constrain accessibility, impinge on cellular potency, and incur greater exposure to disease-causing pathogens based on the donor.
These issues could be circumvented by the derivation of MSCs from pluripotent stem cells.
In this paper, we review methods that induce and characterize MSCs derived from induced pluripotent stem cells (iPSCs) and introduce MSC applications to disease modeling, pathogenic mechanisms, and drug discovery.
We also discuss the potential applications of MSCs in regenerative medicine including cell-based therapies and issues that should be overcome before iPSC-derived MSC therapy will be applied in the clinic.
American Psychological Association (APA)
Zhao, Chengzhu& Ikeya, Makoto. 2018. Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells. Stem Cells International،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1213704
Modern Language Association (MLA)
Zhao, Chengzhu& Ikeya, Makoto. Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells. Stem Cells International No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1213704
American Medical Association (AMA)
Zhao, Chengzhu& Ikeya, Makoto. Generation and Applications of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1213704
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213704