Bone Morphogenetic Protein 6 Inhibits the Immunomodulatory Property of BMMSCs via Id1 in Sjögren’s Syndrome
Joint Authors
Wang, Hao
Su, Yingying
Gu, Yi
Wu, Ruiqing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-02
Country of Publication
Egypt
No. of Pages
9
Abstract EN
Mesenchymal stem cells (MSCs) treatment has emerged as a promising approach for treating Sjögren’s syndrome (SS).
Impaired immunoregulatory activities of bone marrow mesenchymal stem cells (BMMSCs) are found in both SS patients and animal models, and the underlying mechanism is poorly understood.
Increased expression of BMP6 is reported to be related to SS.
The aim herein was to determine the effects of BMP6 on BMMSCs function.
BMMSCs were isolated from SS patients and NOD mice and showed a high level of BMP6 expression.
The effects of BMP6 on BMMSCs function were investigated using in vitro BMMSCs differentiation and in vitro and in vivo T cell proliferation and polarization assays.
BMP6 increased osteogenic differentiation of BMMSCs and inhibited the immunomodulatory properties of BMMSCs.
BMP6 enhanced T cell proliferation and Th1/Th17 differentiation in a T cell-BMMSC coculture system.
Mechanistically, BMP6 downregulated PGE2 and upregulated IFN-gamma via Id1 (inhibitor of DNA-binding protein 1).
Neutralizing BMP6 and knockdown of Id1 could restore the BMMSCs immunosuppressive function both in vitro and in vivo.
The present results suggest a novel role of Id1 in BMP-mediated MSCs function, which may contribute to a better understanding of the mechanism of action of MSCs in treating autoimmune diseases.
American Psychological Association (APA)
Su, Yingying& Gu, Yi& Wu, Ruiqing& Wang, Hao. 2018. Bone Morphogenetic Protein 6 Inhibits the Immunomodulatory Property of BMMSCs via Id1 in Sjögren’s Syndrome. Stem Cells International،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213738
Modern Language Association (MLA)
Su, Yingying…[et al.]. Bone Morphogenetic Protein 6 Inhibits the Immunomodulatory Property of BMMSCs via Id1 in Sjögren’s Syndrome. Stem Cells International No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1213738
American Medical Association (AMA)
Su, Yingying& Gu, Yi& Wu, Ruiqing& Wang, Hao. Bone Morphogenetic Protein 6 Inhibits the Immunomodulatory Property of BMMSCs via Id1 in Sjögren’s Syndrome. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1213738
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213738