N-Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis
Joint Authors
Abay, Solomon M.
Ejigu, Dawit A.
Source
Tuberculosis Research and Treatment
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-04-30
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Oxidative stress is a common feature of tuberculosis (TB), and persons with reduced antioxidants are at more risk of TB.
TB patients with relatively severe oxidative stress had also more advanced disease as measured by the Karnofsky performance index.
Since adverse effects from anti-TB drugs are also mediated by free radicals, TB patients are prone to side effects, such as hearing loss.
In previous articles, researchers appealed for clinical trials aiming at evaluating N-acetyl cysteine (NAC) in attenuating the dreaded hearing loss during multidrug-resistant TB (MDR-TB) treatment.
However, before embarking on such trials, considerations of NAC’s overall impact on TB treatment are crucial.
Unfortunately, such a comprehensive report on NAC is missing in the literature and this manuscript reviews the broader effect of NAC on TB treatment.
This paper discusses NAC’s effect on mycobacterial clearance, hearing loss, drug-induced liver injury, and its interaction with anti-TB drugs.
Based on the evidence accrued to date, NAC appears to have various beneficial effects on TB treatment.
However, despite the favorable interaction between NAC and first-line anti-TB drugs, the interaction between the antioxidant and some of the second-line anti-TB drugs needs further investigations.
American Psychological Association (APA)
Ejigu, Dawit A.& Abay, Solomon M.. 2020. N-Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis. Tuberculosis Research and Treatment،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1213740
Modern Language Association (MLA)
Ejigu, Dawit A.& Abay, Solomon M.. N-Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis. Tuberculosis Research and Treatment No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1213740
American Medical Association (AMA)
Ejigu, Dawit A.& Abay, Solomon M.. N-Acetyl Cysteine as an Adjunct in the Treatment of Tuberculosis. Tuberculosis Research and Treatment. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1213740
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213740