Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies
Joint Authors
Trino, Stefania
Del Vecchio, Luigi
Ambrosino, C.
Laurenzana, Ilaria
Lamorte, Daniela
De Luca, Luciana
Zoppoli, Pietro
Musto, Pellegrino
Caivano, Antonella
Falco, Geppino
Ruggieri, Vitalba
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-27
Country of Publication
Egypt
No. of Pages
11
Abstract EN
The bone marrow (BM) microenvironment in hematological malignancies (HMs) comprises heterogeneous populations of neoplastic and nonneoplastic cells.
Cancer stem cells (CSCs), neoplastic cells, hematopoietic stem cells (HSCs), and mesenchymal stromal/stem cells (MSCs) are all components of this microenvironment.
CSCs are the HM initiators and are associated with neoplastic growth and drug resistance, while HSCs are able to reconstitute the entire hematopoietic system; finally, MSCs actively support hematopoiesis.
In some HMs, CSCs and neoplastic cells compromise the normal development of HSCs and perturb BM-MSCs.
In response, “reprogrammed” MSCs generate a favorable environment to support neoplastic cells.
Extracellular vesicles (EVs) are an important cell-to-cell communication type in physiological and pathological conditions.
In particular, in HMs, EV secretion participates to unidirectional and bidirectional interactions between neoplastic cells and BM cells.
The transfer of EV molecular cargo triggers different responses in target cells; in particular, malignant EVs modify the BM environment in favor of neoplastic cells at the expense of normal HSCs, by interfering with antineoplastic immunity and participating in resistance to treatment.
Here, we review the role of EVs in BM cell communication in physiological conditions and in HMs, focusing on the effects of BM niche EVs on HSCs and MSCs.
American Psychological Association (APA)
Laurenzana, Ilaria& Lamorte, Daniela& Trino, Stefania& De Luca, Luciana& Ambrosino, C.& Zoppoli, Pietro…[et al.]. 2018. Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies. Stem Cells International،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213744
Modern Language Association (MLA)
Laurenzana, Ilaria…[et al.]. Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies. Stem Cells International No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1213744
American Medical Association (AMA)
Laurenzana, Ilaria& Lamorte, Daniela& Trino, Stefania& De Luca, Luciana& Ambrosino, C.& Zoppoli, Pietro…[et al.]. Extracellular Vesicles: A New Prospective in Crosstalk between Microenvironment and Stem Cells in Hematological Malignancies. Stem Cells International. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1213744
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213744