Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats
Joint Authors
Chogtu, Bharti
Ommurugan, Balaji
Thomson, Sereen R.
Kalthur, Sneha G.
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-03-31
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
Objectives.
Statin-induced myopathy is one of the major causes of poor adherence and discontinuation of this medication.
There are contrary results regarding association of vitamin D insufficiency with statin-induced myopathy.
This study was done to determine the effect of the vitamin D3 analogue alfacalcidol on Rosuvastatin-induced myopathy in rats.
Methodology.
Animals were divided into six groups with 6 rats in each group.
Groups I and II acted as controls, Group III and Group IV were administered Rosuvastatin 120 mg/kg/day and 160 mg/kg/day, Groups V and VI were administered alfacalcidol 0.1 μg/kg/day in addition to Rosuvastatin 120 mg/kg/day and 160 mg/kg/day, respectively.
All drugs were administered orally for 15 days.
Plasma creatine kinase (CK) levels were estimated on day 10 and day 15.
Animals were sacrificed and muscles were sent for histopathological examination.
Results.
On day 10, Groups V and VI showed a statistically significant increase in plasma CK levels as compared to the control (p<0.001) and were significantly lower (p<0.001) as compared to Groups III and IV, respectively.
However, on day 15, plasma CK levels in Groups V and VI were comparable to those of control groups with a nonsignificant difference (p>0.05).
On comparing the histology, Groups V and VI showed a significant difference as compared to statin-only groups (Groups III and IV) as there were signs of regeneration, less splitting, and fragmentation of muscle fibres.
Conclusion.
The present study shows that the vitamin D analogue alfacalcidol prevents statin-induced myopathy.
The serum CK levels are comparable to the control group on day 15 of vitamin D administration.
American Psychological Association (APA)
Chogtu, Bharti& Ommurugan, Balaji& Thomson, Sereen R.& Kalthur, Sneha G.. 2020. Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats. The Scientific World Journal،Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1213905
Modern Language Association (MLA)
Chogtu, Bharti…[et al.]. Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats. The Scientific World Journal No. 2020 (2020), pp.1-6.
https://search.emarefa.net/detail/BIM-1213905
American Medical Association (AMA)
Chogtu, Bharti& Ommurugan, Balaji& Thomson, Sereen R.& Kalthur, Sneha G.. Effect of Vitamin D Analogue on Rosuvastatin-Induced Myopathy in Wistar Rats. The Scientific World Journal. 2020. Vol. 2020, no. 2020, pp.1-6.
https://search.emarefa.net/detail/BIM-1213905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1213905