Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach
Joint Authors
Almutairi, Fahad M.
Ajmal, Mohammad Rehan
Alawy, Adel Ibrahim Al
Khan, Rizwan Hasan
Abdelhameed, Ali Saber
Source
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-08-25
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In the present study, we employ fluorescence spectroscopy, dynamic light scattering, and molecular docking methods.
Binding of anticancer drug anastrozole with human lysozyme (HL) is studied.
Binding of anastrozole to HL is moderate but spontaneous.
There is anastrozole persuaded hydrodynamic change in HL, leading to molecular compaction.
Binding of anastrozole to HL also decreased in vitro lytic activity of HL.
Molecular docking results suggest the electrostatic interactions and van der Waals forces played key role in binding interaction of anastrozole near the catalytic site.
Binding interaction of anastrozole to proteins other than major transport proteins in blood can significantly affect pharmacokinetics of this molecule.
Hence, rationalizing drug dosage is important.
This study also points to unrelated effects that small molecules bring in the body that are considerable and need thorough investigation.
American Psychological Association (APA)
Almutairi, Fahad M.& Ajmal, Mohammad Rehan& Alawy, Adel Ibrahim Al& Khan, Rizwan Hasan& Abdelhameed, Ali Saber. 2020. Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach. The Scientific World Journal،Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1214074
Modern Language Association (MLA)
Almutairi, Fahad M.…[et al.]. Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach. The Scientific World Journal No. 2020 (2020), pp.1-7.
https://search.emarefa.net/detail/BIM-1214074
American Medical Association (AMA)
Almutairi, Fahad M.& Ajmal, Mohammad Rehan& Alawy, Adel Ibrahim Al& Khan, Rizwan Hasan& Abdelhameed, Ali Saber. Biophysical Insight into the Interaction of Human Lysozyme with Anticancer Drug Anastrozole: A Multitechnique Approach. The Scientific World Journal. 2020. Vol. 2020, no. 2020, pp.1-7.
https://search.emarefa.net/detail/BIM-1214074
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1214074