Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq
Joint Authors
AL- Salihi, Karima A.
Al-Dabhawi, Ahmed H.
Ajeel, Ali Abbass
Erzuki, Ibrahim A.
Ali, Tho Alfiqar H.
Source
Veterinary Medicine International
Issue
Vol. 2020, Issue 2020 (31 Dec. 2020), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2020-02-21
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The papilloma viruses are constituted of double-stranded DNA and are a more common lesion in ruminant’s skin in Iraq.
The p53 tumor suppressor protein reveals an essential role in cell cycle control.
This study intends to investigate the clinical, histopathological, and immunohistochemical features of cutaneous papilloma in ruminants in Iraq.
Samples had been collected from a total of 10 animals (three cattle, three goats, and four sheep) with multiple papillomatosis lesions.
The samples were processed for histopathological and immunohistochemical techniques.
Clinically, the lesions appeared as multiple various sizes (0.5–11 cm), cauliflower exophytic masses on different parts of the animal’s body.
The histopathological features of the epidermis granular layer revealed perinuclear vacuolation (koilocytosis) accompanied by various degrees of hypergranulosis, hyperkeratosis, acanthosis, orthokeratosis, and parakeratosis.
Strong positive reaction for papillomavirus antigen was seen in both epidermal basal and granular layers in the immunohistochemical investigation (IHC).
Moreover, all papilloma lesions revealed an intense positive p53 reaction in cytoplasmic and perinuclear of the basal and parabasal layers.
In conclusion, this study described the papillomavirus lesions in bovine, ovine, and caprine animals, which were found in different parts areas of the affected animals.
All lesions show similar histopathological features with minor variations.
PV antigen and p53 protein expression showed positive results in immunohistochemistry that can be used as diagnostic markers for ruminant’s papilloma.
American Psychological Association (APA)
AL- Salihi, Karima A.& Al-Dabhawi, Ahmed H.& Ajeel, Ali Abbass& Erzuki, Ibrahim A.& Ali, Tho Alfiqar H.. 2020. Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq. Veterinary Medicine International،Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1214208
Modern Language Association (MLA)
AL- Salihi, Karima A.…[et al.]. Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq. Veterinary Medicine International No. 2020 (2020), pp.1-11.
https://search.emarefa.net/detail/BIM-1214208
American Medical Association (AMA)
AL- Salihi, Karima A.& Al-Dabhawi, Ahmed H.& Ajeel, Ali Abbass& Erzuki, Ibrahim A.& Ali, Tho Alfiqar H.. Clinico-Histopathological and Immunohistochemical Study of Ruminant’s Cutaneous Papillomavirus in Iraq. Veterinary Medicine International. 2020. Vol. 2020, no. 2020, pp.1-11.
https://search.emarefa.net/detail/BIM-1214208
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1214208