Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke
Joint Authors
Borg, Keith
Bauza, Colleen
Martin, Renee’
Yeatts, Sharon D.
Magwood, Gayenell
Selassie, Anbesaw
Ford, Marvella E.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-09
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Although obesity and diabetes mellitus, or diabetes, are independently associated with mortality-related events (e.g., all-cause mortality and cardiovascular-related mortality) following an ischemic stroke, little is known about the joint effect of obesity and diabetes on mortality-related events following an ischemic stroke.
The aim of this study is to evaluate the joint effect of obesity and diabetes on mortality-related events in subjects with a recent ischemic stroke.
Data from the multicenter Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial was analyzed for this study.
The joint effect of obesity and diabetes on mortality-related events was estimated via Cox proportional hazards regression models.
No difference in the hazard of all-cause mortality following an ischemic stroke was observed between obese subjects with diabetes and underweight/normal-weight subjects without diabetes.
In contrast, obese subjects with diabetes had an increased hazard of cardiovascular-related mortality following an ischemic stroke compared with underweight/normal-weight subjects without diabetes.
Additionally, there was evidence of an attributable proportion due to interaction as well as evidence of a highly statistically significant interaction on the multiplicative scale for cardiovascular-related mortality.
In this clinical trial cohort of ischemic stroke survivors, obesity and diabetes synergistically interacted to increase the hazard of cardiovascular-related mortality.
American Psychological Association (APA)
Bauza, Colleen& Martin, Renee’& Yeatts, Sharon D.& Borg, Keith& Magwood, Gayenell& Selassie, Anbesaw…[et al.]. 2018. Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke. Stroke Research and Treatment،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1214846
Modern Language Association (MLA)
Bauza, Colleen…[et al.]. Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke. Stroke Research and Treatment No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1214846
American Medical Association (AMA)
Bauza, Colleen& Martin, Renee’& Yeatts, Sharon D.& Borg, Keith& Magwood, Gayenell& Selassie, Anbesaw…[et al.]. Determining the Joint Effect of Obesity and Diabetes on All-Cause Mortality and Cardiovascular-Related Mortality following an Ischemic Stroke. Stroke Research and Treatment. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1214846
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1214846