Chemoprotective activity of 3-indolylmethyl glucosinolate on induced gastric mucosal injury in male rats

Abstract EN

Mucosal damage in stomach therapy faces a major drawback in modern days due to the unpredictable side effects of the long-term uses of commercially available drugs.

The aim of the present investigation study is to evaluate the chemoprotective activities of 3-indolylmethyl glucosinolate against aspirin-induced gastric mucosal damage in male albino rats.

Rats were divided into two large groups, control group and ulcerated group.

Aspirin (500 mg/kg/body weight for a week), and followed by the beginning of different experimental regimens for a total experimental duration of one month.

Results of the present work showed that, the groups were treated with 3-indolylmethyl glucosinolate possessed protective activity by an increase the mucus level, protein granules and a great number of proliferation cells in the stomach.

So this study suggests that, 3-indolylmethyl glucosinolate possesses significant gastroprotective and antioxidant activities against aspirin-induced gastric ulcer in male albino rats.