In Vitro Study of Deuterium Effect on Biological Properties of Human Cultured Adipose-Derived Stem Cells
Joint Authors
Vasyliev, Roman
Gubar, Olga S.
Gordiienko, Inna M.
Rodnichenko, Anzhela E.
Zlatska, Alona V.
Zubov, Dmytro O.
Syroeshkin, Anton V.
Zlatskiy, Igor A.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-11-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
In current in vitro study we have shown the impact of deuterium content in growth medium on proliferation rate of human cultured adipose-derived stem cells (ADSC).
ADSCs have also demonstrated morphological changes when cultured in deuterated growth medium: the cell cultures did not reach confluence but acquired polygonal morphology with pronounced stress fibers.
At high deuterium concentrations the ADSCs population doubling time increased which indicated the cell cycle retardation and decrease of cell proliferation rate.
The deuterated and deuterium-depleted growth media demonstrated acute and chronic cytotoxicity, respectively.
The minimal migration ability was observed in deuterated medium whereas the highest migration activity was observed in the medium with the deuterium content close to natural.
The cells in deuterated growth medium demonstrated decrease in metabolic activity after three days in culture.
In contrast, in deuterium-depleted medium there was an increase in ADSC metabolic activity.
American Psychological Association (APA)
Zlatska, Alona V.& Gordiienko, Inna M.& Vasyliev, Roman& Zubov, Dmytro O.& Gubar, Olga S.& Rodnichenko, Anzhela E.…[et al.]. 2018. In Vitro Study of Deuterium Effect on Biological Properties of Human Cultured Adipose-Derived Stem Cells. The Scientific World Journal،Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1215631
Modern Language Association (MLA)
Zlatska, Alona V.…[et al.]. In Vitro Study of Deuterium Effect on Biological Properties of Human Cultured Adipose-Derived Stem Cells. The Scientific World Journal No. 2018 (2018), pp.1-10.
https://search.emarefa.net/detail/BIM-1215631
American Medical Association (AMA)
Zlatska, Alona V.& Gordiienko, Inna M.& Vasyliev, Roman& Zubov, Dmytro O.& Gubar, Olga S.& Rodnichenko, Anzhela E.…[et al.]. In Vitro Study of Deuterium Effect on Biological Properties of Human Cultured Adipose-Derived Stem Cells. The Scientific World Journal. 2018. Vol. 2018, no. 2018, pp.1-10.
https://search.emarefa.net/detail/BIM-1215631
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1215631