Association of adipocyte fatty acid-binding protein (FABP4)‎ level with obesity in women

Abstract EN

Adipocyte Fatty Acid–Binding Protein(FABP 4) is produced by mature adipocytes, cytoplasmic lipid protein carrier, 132 amino acid and secretion increases during adipogenesis.

Chemerin is adipocytokine anewly discovered novel adipokine that regulates adipocyte metabolism and adipogenesis, is The aim of this study is to investigated the relationship of chemerin and FABP4 level with obesity and identifing the usefulness of waist circumference (WC), hip circumference , waist-to-hip ratio (WHR), body mass index (BMI),, and body fat percentage( BF%) in screening obesity .

Anthropometric data were collected for 180 healthy women with an age range 35-60 years, divided into four groups due to body mass index: normalweight (18.5-24.9 kg/m2 ), overweight (25-29.9 kg/m2 ) , obese (30-39.9 kg/m2 ) and morbid(≥ 40 kg/m2 ).

The results revealed that FABP4 and Chemerin circulating concentration were significantly increased (P<0.01) in healthy morbid and obese adult women when compared with lean healthy (normal and over weight women ) also significant increase of A-FABP and Chemerin with the body mass index (BMI), waist hip ratio, hip circumference, waist circumference, and with BF percentage.

According to these finding suggest that the circulating chemerin and A-FABP levels can be used as Prediction marker of overall fat mass and obesity in women.