Evaluation the role of interleukin-8 and interleukin-10 in myocardial infarction patients in al-Najaf city

Abstract EN

This study conducted to evaluate the interleukin-8 and interleukin- 10 level in hypertension and myocardial infarction patients in the period from March to December 2018 by using ELISA technique .A total of thirty three (33) patients from which (5 women and 8 men) with MI and (7 women and 4 men) with hypertension and a total of 19 (7 women and 12 men) healthy individuals were considered as control group .Resulting in, the mean of interleukin-8 level of hypertension and myocardial infarction patients (416.6 pg/ml) and (433.2pg/ml) respectively, with significant elevation comparing with non hypertension (292.03 pg/ml), non myocardial patients (378.9 pg/ml) and control (123.1 pg/ml), furthermore, mean of interleukin-10 level of hypertension and myocardial infarction patients (320.5pg/ml) and (102.9 pg/ml) respectively, with significantly different compared with non patients and control, where show significant increase mean of interleukin-10 level of hypertension compared with non hypertension patients (260.5 pg/ml) and control (129.4 pg/ml), also show a significant decline mean of interleukin-10 level for myocardial in comparison with non myocardial patients (146.3 pg/ml) and control (129.4 pg/ml) .)Concluded that interleukin-8( pro and anti- inflammatory )significantly raised in hypertension and myocardial infarction in coronary artery patients, in contrast, this result observed decrease production of anti-inflammatory cytokines IL-10 in myocardial patients.