Synthesis and study on biological effect of the (1E, 4E)-1,5- bis (4-nitrophenyl) penta-1,4-dien-3-one
Parallel Title
Joint Authors
Miftah, Muhammad Sad
Shaybani, Muhammad Abd al-Salam
Ziyad, Jalal M.
Source
Journal of Humanitarian and Applied Sciences
Issue
Vol. 4, Issue 8 (31 Dec. 2019), pp.357-366, 10 p.
Publisher
Elmergib University Faculty of Art & Science / Kasr Khiar
Publication Date
2019-12-31
Country of Publication
Libya
No. of Pages
10
Main Subjects
Abstract EN
The (1E,4E)-1,5-bis (4-nitrophenyl) penta-1,4-dien-3-one (3) was synthesized by treatment of acetone with 4-nitrobenzaldehyde using 1:2 mol.
respectively in the presence of basic medium of sodium hydroxide in a good yield.
The structure of the prepared compound was characterized by elemental analysis, IR,1H-NMR, and mass spectra.
The newly prepared compound was screened for the antibacterial activity against Escherichia coli (G-) and Staphylococcus aureus (G+) bacterial strains by the disc diffusion method, and for their antifungal activity against Aspergillus flavus and Candida albicans in N,Ndimethylformamide by the agar diffusion method.
The results of the test compound exhibited low cadre of antibacterial and antifungal activities compared with the standard drug Amikacin, therefore, minimum bactericidal concentration (MBC) and minimum fungicidal concentration (MFC) were not determined for the test compound.
American Psychological Association (APA)
Miftah, Muhammad Sad& Shaybani, Muhammad Abd al-Salam& Ziyad, Jalal M.. 2019. Synthesis and study on biological effect of the (1E, 4E)-1,5- bis (4-nitrophenyl) penta-1,4-dien-3-one. Journal of Humanitarian and Applied Sciences،Vol. 4, no. 8, pp.357-366.
https://search.emarefa.net/detail/BIM-1225056
Modern Language Association (MLA)
Miftah, Muhammad Sad…[et al.]. Synthesis and study on biological effect of the (1E, 4E)-1,5- bis (4-nitrophenyl) penta-1,4-dien-3-one. Journal of Humanitarian and Applied Sciences Vol. 4, no. 8 (Dec. 2019), pp.357-366.
https://search.emarefa.net/detail/BIM-1225056
American Medical Association (AMA)
Miftah, Muhammad Sad& Shaybani, Muhammad Abd al-Salam& Ziyad, Jalal M.. Synthesis and study on biological effect of the (1E, 4E)-1,5- bis (4-nitrophenyl) penta-1,4-dien-3-one. Journal of Humanitarian and Applied Sciences. 2019. Vol. 4, no. 8, pp.357-366.
https://search.emarefa.net/detail/BIM-1225056
Data Type
Journal Articles
Language
English
Notes
Record ID
BIM-1225056