In vitro and in vivo inhibition of Gammarus pulex acetylcholinesterase by diazinon
Joint Authors
Mills, Chris Lloyd
al-Wahishi, Salim Salih
Muhammad, Wisam F. A.
Hargreaves, Alan
Source
Scientific Journal of Faculty of Education
Issue
Vol. 5, Issue 12 (31 Mar. 2019), pp.14-27, 14 p.
Publisher
Misurata University Faculty of Education
Publication Date
2019-03-31
Country of Publication
Libya
No. of Pages
14
Main Subjects
Information Technology and Computer Science
Topics
Abstract EN
This study was designed to investigate the effect of the in vivo and in vitro exposure to the organophosphorothioate pesticide diazinon, its metabolite diazinon oxon and diazinon in a commercial formulation on the AChE activity of the freshwater amphipod Gammarus pulex.
Only diazinon oxon at concentrations of ≥ 50x103 nM oxon caused a significant inhibition of acetylcholinesterase (AChE) activity in vitro.
However, diazinon oxon had no significant impact on the enzyme activity following in vivo exposure.
The latter mode of exposure to either ≥ 10 nM of diazinon or ≥ 5 nM of the diazinon in the commercial formulation caused a significant reduction in AChE activity of treated organisms.
This study supports the finding of previous studies that suggested AChE activity in aquatic animals as a valuable biomarker of diazinon.
American Psychological Association (APA)
al-Wahishi, Salim Salih& Muhammad, Wisam F. A.& Hargreaves, Alan& Mills, Chris Lloyd. 2019. In vitro and in vivo inhibition of Gammarus pulex acetylcholinesterase by diazinon. Scientific Journal of Faculty of Education،Vol. 5, no. 12, pp.14-27.
https://search.emarefa.net/detail/BIM-1226606
Modern Language Association (MLA)
al-Wahishi, Salim Salih…[et al.]. In vitro and in vivo inhibition of Gammarus pulex acetylcholinesterase by diazinon. Scientific Journal of Faculty of Education Vol. 5, no. 12 (Mar. 2019), pp.14-27.
https://search.emarefa.net/detail/BIM-1226606
American Medical Association (AMA)
al-Wahishi, Salim Salih& Muhammad, Wisam F. A.& Hargreaves, Alan& Mills, Chris Lloyd. In vitro and in vivo inhibition of Gammarus pulex acetylcholinesterase by diazinon. Scientific Journal of Faculty of Education. 2019. Vol. 5, no. 12, pp.14-27.
https://search.emarefa.net/detail/BIM-1226606
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 25-27
Record ID
BIM-1226606