Effect of dietary bidens pilosa L. leaves on rats suffering from acute liver toxicity

Abstract AR

The study aimed to reveal the effect of three levels of Bidens pilosa L.

(Asteraceae) leaves powder 2.5, 5 and 10 % on acute liver hepatotoxicity.

Forty adult albino male rats Sprague Dawley strain were classified into five groups.

One was fed on basal diet and kept as control (-ve) group.

The other four hepatic rat groups were control group (+ve), 2.5, 5 and 10% BPP groups.

At the end of the experimental period rats were fasted overnight and sacrificed, blood samples were collected from the aorta to determine lipids profiles and liver functions.

Also, nutritional and biological parameters were recorded as well as histopahological studies for liver.

The obtained results revealed that, injecting rats by CCL4 led to significant increase in acute liver toxicity, and increase in (triglycerides, LDL-c, ALT, AST and ALP).

Feeding rats on basal diet supplemented with different levels from Bidens pilosa L.

powder improved all parameters, reduced serum total cholesterol (TC), triglycerides (TG), low density lipoprotein cholesterol (LDL-c), and liver enzymes, while there was increase in serum high density lipoprotein cholesterol (HDL-c), and food intake especially when the high level 10% BPP is used.

From the obtained results it can be concluded that, supplementation of bakery product with Bidens pilosa L.

leaves powder exerts a positive impact on the liver functions, lipid profile and other biochemical parameters.