Effects of qat water extract combined with sublethal dose of cypermethrin on fetuses body weight and length of pregnant mice

Abstract EN

The effect of Qat water extract and sublethal concentration of Cypermethrin as active ingredient (A.I.) or formulated type (F) alone or in combination with Qat was evaluated on mice fetuses body weight and length.

Female mice were exposed to these treatments during 6 th – 18th day of gestation.

The results showed that there were significant reduction in mice fetuses body weight and length due to the administration of Qat extract alone, Cypermethrin alone, or the combinations of 5g/kg Qat extract with the respective sublethal dose of 1/10 th LD50 (25 mg/kg) of either insecticide type.

The formulated Cypermethrin (F) was more effective than its active ingredient type in all experiments, where the tested commercial formulation of Cypermethrin (Cymbush® 10 % E.C.) showed a dramatic significant reduction in the fetuses body weight and length compared with the control.

The reduction of body weight and length was higher in case of Qat extract (5g/kg) + 1/10 th LD50 of Cypermethrin formulation treatment with a mean reduction percentage of 40.00% of fetuses body weight and 59.31% of fetuses body length, while the mean reduction percentages for Cypermethrin (A.I.) were 36.24% and 51.91%, respectively.

Qat extract alone had a reduction percentage of 15.07% of fetuses body weight.

It could be concluded that there is might be high a risk for those pregnant women who comsume Qat.