التقدير الطيفي لكبريتات السالبيوتامول و حامض الميفيناميك باستخدام صبغة الأزور-A بوجود العامل المؤكسد N-بروموسكسينميد

Other Title(s)

Spectrophotometric determination of salbutamol sulphate and mefenamic acid using azur-A dye in presence of oxidizing agent N-bromosuccinimide

Joint Authors

المتيوتي، صبحي محسن جار الله
الهاشمي، أسماء حمزة عباس

Source

التربية و العلم : مجلة علمية للبحوث العلمية الأساسية

Issue

Vol. 29, Issue 4 (31 Dec. 2020), pp.222-244, 23 p.

Publisher

University of Mosul College of Education for Pure Science

Publication Date

2020-12-31

Country of Publication

Iraq

No. of Pages

23

Main Subjects

Chemistry

Topics

Abstract EN

A simple, accurate and sensitive indirect spectrophotometric method has been developed for the determination of salbutamol sulphate and mefenamic acid in pure forms and in pharmaceutical preparations (capsule, syrup, tablet).

This method based on the bromination of the drug with N-bromosuccinimide in acidic medium and the unreacted oxidizing agent react with constant amount of Azur-A dye solution due to bleach their colour and measured the orbance of the residual colour dye at 606.5 nm.

The molar orptivity for salbutamol sulphate and mefenamic acid are 2.3 × 104 L.

mol-1.

cm-1 and 8.1× 103 L.

mol-1.

cm-1 respectively.

Beer's Law was obeyed over the concentration range of 1.6 -12.8 µg/ml for salbutamol sulphate and1.6 -13.6 µg/ml for mefenamic acid.

The limit of detection (LOD) were 0.0367µg/ml and limit of quantitation (LOQ) were 0.1226 µg/ml for both drugs.

In addition, the recovery levels of the drugs were in the range 100.56% and 100.74% .

The method was created to be simple, cost-effective and rapid because it does not involve any solvent extraction.

The developed method was successfully applied for the determination of the studied drugs.

A simple, accurate and sensitive indirect spectrophotometric method has been developed for the determination of salbutamol sulphate and mefenamic acid in pure forms and in pharmaceutical preparations (capsule, syrup, tablet).

This method based on the bromination of the drug with N-bromosuccinimide in acidic medium and the unreacted oxidizing agent react with constant amount of Azur-A dye solution due to bleach their colour and measured the orbance of the residual colour dye at 606.5 nm.

The molar orptivity for salbutamol sulphate and mefenamic acid are 2.3 × 104 L.

mol-1.

cm-1 and 8.1× 103 L.

mol-1.

cm-1 respectively.

Beer's Law was obeyed over the concentration range of 1.6 -12.8 µg/ml for salbutamol sulphate and1.6 -13.6 µg/ml for mefenamic acid.

The limit of detection (LOD) were 0.0367µg/ml and limit of quantitation (LOQ) were 0.1226 µg/ml for both drugs.

In addition, the recovery levels of the drugs were in the range 100.56% and 100.74% .

The method was created to be simple, cost-effective and rapid because it does not involve any solvent extraction.

The developed method was successfully applied for the determination of the studied drugs

American Psychological Association (APA)

الهاشمي، أسماء حمزة عباس والمتيوتي، صبحي محسن جار الله. 2020. التقدير الطيفي لكبريتات السالبيوتامول و حامض الميفيناميك باستخدام صبغة الأزور-A بوجود العامل المؤكسد N-بروموسكسينميد. التربية و العلم : مجلة علمية للبحوث العلمية الأساسية،مج. 29، ع. 4، ص ص. 222-244.
https://search.emarefa.net/detail/BIM-1235538

Modern Language Association (MLA)

الهاشمي، أسماء حمزة عباس والمتيوتي، صبحي محسن جار الله. التقدير الطيفي لكبريتات السالبيوتامول و حامض الميفيناميك باستخدام صبغة الأزور-A بوجود العامل المؤكسد N-بروموسكسينميد. التربية و العلم : مجلة علمية للبحوث العلمية الأساسية مج. 29، ع. 4 (2020)، ص ص. 222-244.
https://search.emarefa.net/detail/BIM-1235538

American Medical Association (AMA)

الهاشمي، أسماء حمزة عباس والمتيوتي، صبحي محسن جار الله. التقدير الطيفي لكبريتات السالبيوتامول و حامض الميفيناميك باستخدام صبغة الأزور-A بوجود العامل المؤكسد N-بروموسكسينميد. التربية و العلم : مجلة علمية للبحوث العلمية الأساسية. 2020. مج. 29، ع. 4، ص ص. 222-244.
https://search.emarefa.net/detail/BIM-1235538

Data Type

Journal Articles

Language

Arabic

Notes

يتضمن مراجع ببليوجرافية : ص. 242-244

Record ID

BIM-1235538