Effect of some plant extracts on hyperprolactinemia in experimental animals
Other Title(s)
تأبير بعض المستخلصات النباتية على البرولاكتين المرتفع في حيوانات التجارب
Joint Authors
Ibrahim, Himmat Abd al-Fattah
Muhammad, Anan Atif Muhammad
Muawwad, Faruq Jundi
Tawfiq, Majdi Fuad
Source
Arab Universities Journal of Agricultural Sciences
Issue
Vol. 28, Issue 4 (31 Dec. 2020), pp.1031-1039, 9 p.
Publisher
Ain Shams University Faculty of Agriculture
Publication Date
2020-12-31
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Topics
- Addiction
- Bones
- Sex hormones
- Laboratory animals
- Bone density
- Cancer
- Analytical chemistry
- Connective tissues
- Laboratory diagnosis
- Drugs
- Breast
- Blood
- Narcotics drugs
- Plant extracts
- Follicle-stimulating hormone
- Impotence
- Luteinizing hormone
Abstract EN
Hyperprolactinaemia is the occurrence of an endocrine disorder that leads to an increase in the level of the hormone prolactin (PRL) in the blood above normal levels in cases other than the natural increase in pregnancy and lactation.
It may be present as the menstrual disturbances, galactorrhea, sexual dysfunction, gynecomastia, infertility, decreased bone mineral density, and breast cancer.
This increase results from several causes that may be pathological such as pituitary tumors, psychological such as stress, or as a result of taking a specific drug such as schizophrenia, anti-vomiting drugs, nerve analgesics, first-generation antipsychotics, hypnotics, and sedatives.
Hyperprolactinaemia by metoclopramide was induced in male and female rats to assess the therapeutic effects of alcoholic extracts of sage leaves, marjoram leaves and celery seeds.
Through the biochemical analysis of blood hormones, the results showed that treating rats with metoclopramide drug (150 mg / kg / day) for a week had an effect on the positive control group in the occurrence of hyperprolactinaemia compared to the negative control group at the beginning of the experiment.
The results indicated that there was a significant effect (P<0.05) for the three plant extracts namely marjoram leaves, sage leaves and celery seeds ( 250 mg / kg / day) for 30 days, to reduce the prolactin hormone in the blood and also to maintain the level of the rest of the sex hormones (progesterone (PRG), estrogen (E2), testosterone (TST), Follicle-stimulating hormone (FSH) and Luteinizing hormone (LH)) without causing any disturbance in males and females in comparison to the group of drug used in the experiment.
To treat this condition bromocriptine (Dopamine receptors agonist) is used.
The rats returned to normal case after the appearance of the rats' recovery after taking the extracts during the trial period.
This effect may be due to estrogen receptors and /or dopamine receptor
American Psychological Association (APA)
Muhammad, Anan Atif Muhammad& Tawfiq, Majdi Fuad& Ibrahim, Himmat Abd al-Fattah& Muawwad, Faruq Jundi. 2020. Effect of some plant extracts on hyperprolactinemia in experimental animals. Arab Universities Journal of Agricultural Sciences،Vol. 28, no. 4, pp.1031-1039.
https://search.emarefa.net/detail/BIM-1240545
Modern Language Association (MLA)
Muhammad, Anan Atif Muhammad…[et al.]. Effect of some plant extracts on hyperprolactinemia in experimental animals. Arab Universities Journal of Agricultural Sciences Vol. 28, no. 4 (2020), pp.1031-1039.
https://search.emarefa.net/detail/BIM-1240545
American Medical Association (AMA)
Muhammad, Anan Atif Muhammad& Tawfiq, Majdi Fuad& Ibrahim, Himmat Abd al-Fattah& Muawwad, Faruq Jundi. Effect of some plant extracts on hyperprolactinemia in experimental animals. Arab Universities Journal of Agricultural Sciences. 2020. Vol. 28, no. 4, pp.1031-1039.
https://search.emarefa.net/detail/BIM-1240545
Data Type
Journal Articles
Language
English
Notes
-
Record ID
BIM-1240545