Urinary podocalyxin : is it a real index of disease activity in Egyptian patients lupus nephritis
Joint Authors
al-Nukiti, Mahmud M.
Fayid, Ahmad
Hammad, Hani
Sulayman, Dina Hisham Ahmad
Ahmad, Riham Abd al-Ghani
al-Yamani, Muhammad
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 31, Issue 6 (31 Dec. 2020), pp.1198-1205, 8 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2020-12-31
Country of Publication
Saudi Arabia
No. of Pages
8
Main Subjects
Abstract EN
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease characterized by production of a number of antinuclear antibodies.
Podocyte injury is an important feature and can be detected by several markers including podocalyxin.
We aimed to evaluate the impact of SLE on urinary levels of podocalyxin and to determine its relationship to renal biopsy, proteinuria, and disease activity in lupus nephritis (LN) patients.
Sixty individuals were recruited; 30 SLE patients with LN as well as 30 healthy volunteers and they were subjected to full history, clinical examination, kidney function, protein/creatinine ratio, urinary podocalyxin, and kidney biopsy.
Patients with LN had higher level of urinary podocalyxin (3.96 ± 2.24) than the other group (0 ± 0), (P <0.001).
Class IV LN was the most common class found among LN patients [18 cases (60%)].
There was a statistically significant positive correlation between SLE disease activity index score, protein/creatinine ratio, and urinary podocalyxin (P <0.001, r = 0.98) (P <0.001, r = 0.765).
There was a statistically significant negative correlation between serum albumin, serum calcium, and urinary podocalyxin (P = 0.001, r = -0.589) (P = 0.025, r = -0.407).
Urinary podocalyxin level significantly predicts the pathological impact of SLE on the kidney and could be used as a noninvasive marker for such effect and its progression.
American Psychological Association (APA)
Fayid, Ahmad& al-Nukiti, Mahmud M.& al-Yamani, Muhammad& Hammad, Hani& Sulayman, Dina Hisham Ahmad& Ahmad, Riham Abd al-Ghani. 2020. Urinary podocalyxin : is it a real index of disease activity in Egyptian patients lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 6, pp.1198-1205.
https://search.emarefa.net/detail/BIM-1242004
Modern Language Association (MLA)
Fayid, Ahmad…[et al.]. Urinary podocalyxin : is it a real index of disease activity in Egyptian patients lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 6 (Nov. / Dec. 2020), pp.1198-1205.
https://search.emarefa.net/detail/BIM-1242004
American Medical Association (AMA)
Fayid, Ahmad& al-Nukiti, Mahmud M.& al-Yamani, Muhammad& Hammad, Hani& Sulayman, Dina Hisham Ahmad& Ahmad, Riham Abd al-Ghani. Urinary podocalyxin : is it a real index of disease activity in Egyptian patients lupus nephritis. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 6, pp.1198-1205.
https://search.emarefa.net/detail/BIM-1242004
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1204-1205
Record ID
BIM-1242004