Primary sinonasal no-hodgkin's lymphoma : our experiences at a tertiary care teaching hospital of eastern India

Abstract EN

Background: Primary sinonasal non‑Hodgkin's lymphomas (NHLs) are uncommon malignancies.

The lack of specific clinical presentations often causes delayed visit to the clinician and so diagnosis is done in late with advanced stage.

Objective: The objective of the study was to study the primary sinonasal NHL with respect to clinical presentations, management, and outcome.

Materials and Methods: This is a retrospective study conducted in a tertiary care teaching hospital from March 2010 to April 2020.

The clinical data of the patients of primary sinonasal NHL were evaluated with respect to the age, sex, clinical presentations, staging, diagnosis, treatment, and outcome.

Results: The mean age of the participants was 62.45 years with male‑to‑female ratio of 1.5: 1.

All the cases of sinonasal NHL involved with paranasal sinuses and nasal cavity.

Nasal obstruction was the most common symptom.

All were diagnosed with large B‑cell lymphoma and treated with combined chemotherapy and radiation.

Five patients were died during follow‑up period.

Conclusion: Primary sinonasal NHLs are extremely uncommon clinical entity.

The diagnosis is based on the histological examination with immunohistochemical study.

Early diagnosis and prompt treatment with chemo‑regimen and radiotherapy are essential to achieve an optimum outcome.

Early diagnosis and treatment improves the treatment are uncommon malignancies.

The lack of specific clinical presentations often causes delayed visit to the clinician and so diagnosis is done in late with advanced stage.

Objective: The objective of the study was to study the primary sinonasal NHL with respect to clinical presentations, management, and outcome.

Materials and Methods: This is a retrospective study conducted in a tertiary care teaching hospital from March 2010 to April 2020.

The clinical data of the patients of primary sinonasal NHL were evaluated with respect to the age, sex, clinical presentations, staging, diagnosis, treatment, and outcome.

Results: The mean age of the participants was 62.45 years with male‑to‑female ratio of 1.5: 1.

All the cases of sinonasal NHL involved with paranasal sinuses and nasal cavity.

Nasal obstruction was the most common symptom.

All were diagnosed with large B‑cell lymphoma and treated with combined chemotherapy and radiation.

Five patients were died during follow‑up period.

Conclusion: Primary sinonasal NHLs are extremely uncommon clinical entity.

The diagnosis is based on the histological examination with immunohistochemical study.

Early diagnosis and prompt treatment with chemo‑regimen and radiotherapy are essential to achieve an optimum outcome.

Early diagnosis and treatment improves the treatment outcome.