Screening for latent tuberculosis infection at a rheumatology and medical rehabilitation center in Duhok city, Iraq
Joint Authors
Yusuf, Shawkat Sabri
Rasul, Muhammad Tahir
Source
Issue
Vol. 18, Issue 1 (31 Mar. 2021), pp.23-27, 5 p.
Publisher
University of Babylon College of Medicine
Publication Date
2021-03-31
Country of Publication
Iraq
No. of Pages
5
Main Subjects
Topics
Abstract EN
Background: Patients with rheumatoid diseases are at increased risk of infection due to a combination of inherent energy or immunomodulating drugs used for its treatment.
The study aimed to screen for latent tuberculosis infection (LTBI) among patients with rheumatologic diseases.
Materials and Methods: In the present prospective cross‑sectional study, a total of 149 patients diagnosed with different types of rheumatoid diseases were included.
The rheumatic diseases were diagnosed based on the American College of Rheumatology criteria for rheumatoid arthritis (RA) or the European Spondyloarthropathy Study Group preliminary criteria for the classification of spondyloarthropathy.
The patients were screened by interferon‑gamma release assay and tuberculin skin tests using purified protein derivative.
Results: The mean age of the patients was 39.91.
The most common types of diseases were ankylosing spondylitis (37.6% ) and RA (34.9% ).
The prevalence rate of LTBI was 12.1% among rheumatic patients.
The patients with positive LTBI had significantly longer therapy duration (4.51 vs.
2.81 years, P < 0.001) and were older (48.61 vs.
38.72 years, P = 0.005), respectively.
There was no statistically significant association between the disease types and LTBI positivity (P = 0.512).
However, LTBI positive was more prevalent in patients who received rituximab (16.7% ; P = 0.035) and those patients with past medical history (20.9% vs.
8.5% , respectively; P = 0.035) and those did not receive the bacillus Calmette–Guérinvaccination (36.4% vs.
10.1% ; P = 0.029).
Conclusions: This study suggests that patients with rheumatoid diseases and treated with anti‑tumor necrosis factor therapies are at an increased risk of tuberculosis Background: Patients with rheumatoid diseases are at increased risk of infection due to a combination of inherent energy or immunomodulating drugs used for its treatment.
The study aimed to screen for latent tuberculosis infection (LTBI) among patients with rheumatologic diseases.
Materials and Methods: In the present prospective cross‑sectional study, a total of 149 patients diagnosed with different types of rheumatoid diseases were included.
The rheumatic diseases were diagnosed based on the American College of Rheumatology criteria for rheumatoid arthritis (RA) or the European Spondyloarthropathy Study Group preliminary criteria for the classification of spondyloarthropathy.
The patients were screened by interferon‑gamma release assay and tuberculin skin tests using purified protein derivative.
Results: The mean age of the patients was 39.91.
The most common types of diseases were ankylosing spondylitis (37.6% ) and RA (34.9% ).
The prevalence rate of LTBI was 12.1% among rheumatic patients.
The patients with positive LTBI had significantly longer therapy duration (4.51 vs.
2.81 years, P < 0.001) and were older (48.61 vs.
38.72 years, P = 0.005), respectively.
There was no statistically significant association between the disease types and LTBI positivity (P = 0.512).
However, LTBI positive was more prevalent in patients who received rituximab (16.7% ; P = 0.035) and those patients with past medical history (20.9% vs.
8.5% , respectively; P = 0.035) and those did not receive the bacillus Calmette–Guérinvaccination (36.4% vs.
10.1% ; P = 0.029).
Conclusions: This study suggests that patients with rheumatoid diseases and treated with anti‑tumor necrosis factor therapies are at an increased risk of tuberculosis infection.
American Psychological Association (APA)
Yusuf, Shawkat Sabri& Rasul, Muhammad Tahir. 2021. Screening for latent tuberculosis infection at a rheumatology and medical rehabilitation center in Duhok city, Iraq. Medical Journal of Babylon،Vol. 18, no. 1, pp.23-27.
https://search.emarefa.net/detail/BIM-1248147
Modern Language Association (MLA)
Yusuf, Shawkat Sabri& Rasul, Muhammad Tahir. Screening for latent tuberculosis infection at a rheumatology and medical rehabilitation center in Duhok city, Iraq. Medical Journal of Babylon Vol. 18, no. 1 (Jan. / Mar. 2021), pp.23-27.
https://search.emarefa.net/detail/BIM-1248147
American Medical Association (AMA)
Yusuf, Shawkat Sabri& Rasul, Muhammad Tahir. Screening for latent tuberculosis infection at a rheumatology and medical rehabilitation center in Duhok city, Iraq. Medical Journal of Babylon. 2021. Vol. 18, no. 1, pp.23-27.
https://search.emarefa.net/detail/BIM-1248147
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 27
Record ID
BIM-1248147