Effect of different doses of pumpkin seed oil on liver function in adult male rats treated with chlorpyrifos
Joint Authors
al-Kalbi, Jasim Muhammad Ahmad
Abd, Nabil Mahdi
Source
Issue
Vol. 16, Issue 1 (31 Mar. 2021), pp.98-111, 14 p.
Publisher
University of Thi-Qar Research and Development Department
Publication Date
2021-03-31
Country of Publication
Iraq
No. of Pages
14
Main Subjects
Topics
Abstract EN
They present study aimed to investigate the effect of effect of different doses of pumpkin seed oil on liver function in adult male rats treated with chlorpyrifos.
Fifty adult male rats were used and randomly divided into five equal groups of 10 rats each group.
Group 1(control) were given corn oil (1ml /kg.
bw), whereas animals of Group 2 were given CPF 6.7 mg/kg bw in corn oil.
Group 3, 4 and 5 were given CPF (6.7mg /kg.
bw) plus PSO (20, 40, and 80) mg/kg.
bw respectively.
The treatment were given once daily by oral gavages for 8 weeks.
At the end of the experiment, animals were sacrificed and serum isolated from blood samples were used for measurement of liver enzymes and liver samples were taken for histopathological study.
Chlorpyrifos treated group recorded significant increase(p<0.05)in aspartate aminotransferase(AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) and histopathological examination of liver revealed marked congestion in the centrilobular area with hepatocellular necrosis.
On other hand groups treated with 20, 40and 80 mg pumpkin seed oil induced improved of these They present study aimed to investigate the effect of effect of different doses of pumpkin seed oil on liver function in adult male rats treated with chlorpyrifos.
Fifty adult male rats were used and randomly divided into five equal groups of 10 rats each group.
Group 1(control) were given corn oil (1ml /kg.
bw), whereas animals of Group 2 were given CPF 6.7 mg/kg bw in corn oil.
Group 3, 4 and 5 were given CPF (6.7mg /kg.
bw) plus PSO (20, 40, and 80) mg/kg.
bw respectively.
The treatment were given once daily by oral gavages for 8 weeks.
At the end of the experiment, animals were sacrificed and serum isolated from blood samples were used for measurement of liver enzymes and liver samples were taken for histopathological study.
Chlorpyrifos treated group recorded significant increase(p<0.05)in aspartate aminotransferase(AST), alanine aminotransferase (ALT) and alkaline phosphatase (ALP) and histopathological examination of liver revealed marked congestion in the centrilobular area with hepatocellular necrosis.
On other hand groups treated with 20, 40and 80 mg pumpkin seed oil induced improved of these parameters
American Psychological Association (APA)
Abd, Nabil Mahdi& al-Kalbi, Jasim Muhammad Ahmad. 2021. Effect of different doses of pumpkin seed oil on liver function in adult male rats treated with chlorpyrifos. University of Thi-Qar Journal،Vol. 16, no. 1, pp.98-111.
https://search.emarefa.net/detail/BIM-1248204
Modern Language Association (MLA)
Abd, Nabil Mahdi& al-Kalbi, Jasim Muhammad Ahmad. Effect of different doses of pumpkin seed oil on liver function in adult male rats treated with chlorpyrifos. University of Thi-Qar Journal Vol. 16, no. 1 (Mar. 2021), pp.98-111.
https://search.emarefa.net/detail/BIM-1248204
American Medical Association (AMA)
Abd, Nabil Mahdi& al-Kalbi, Jasim Muhammad Ahmad. Effect of different doses of pumpkin seed oil on liver function in adult male rats treated with chlorpyrifos. University of Thi-Qar Journal. 2021. Vol. 16, no. 1, pp.98-111.
https://search.emarefa.net/detail/BIM-1248204
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 107-111
Record ID
BIM-1248204