![](/images/graphics-bg.png)
Thrombotic microangiopathy in a renal allograft : single-center Five-year experience
Joint Authors
Nigam, Lovelesh A.
Thakkar, Umang G.
Mehta, Aanal H.
Vanikar, Aruna V.
Patel, Rashmi D.
Kanodia, Kamal V.
Suthar, Kamlesh S.
Source
Saudi Journal of Kidney Diseases and Transplantation
Issue
Vol. 31, Issue 6 (31 Dec. 2020), pp.1331-1343, 13 p.
Publisher
Saudi Center for Organ Transplantation
Publication Date
2020-12-31
Country of Publication
Saudi Arabia
No. of Pages
13
Main Subjects
Abstract EN
Thrombotic microangiopathy (TMA) is devastating for renal transplantation (RT) causing graft/ patient loss.
We present 5-year experience of TMA in RT in retrospective study of indicated renal allograft biopsies with TMA.
Patient–donor demographics and associated histological findings with respect to transplants under tolerance induction protocol (Group 1) were compared with patients transplanted under triple immunosuppression (Group 2).
Statistical analysis was performed using IBM SPSS Statistics version 20.
Sixty-one (4.1%) of 1520 biopsies [Group 1:17 (1.9%)/882, Group 2:44 (6.9%)/638] revealed TMA.
Tacrolimus trough levels were normal.
There was no evidence of systemic involvement in any patient.
Mean age was 36.8 years with 70.6% males, HLA-match, 2.6/6, and the most common original disease unknown (41.2%) in Group 1, and 35.9 years with 86.4% males, HLA-match, 2.1/6, and the most common original disease unknown (50%) in Group 2.
Biopsies were performed at mean 5.1-year posttransplant in Group 1 and 2.3 years in Group 2.
Acute TMA constituted 47% Group 1 and 43.2% Group 2 biopsies; of these, antibody-mediated rejections were observed in 58.8%, T-cell mediated rejections in 11.8%, tacrolimus toxicity in 76.5%, and other findings in 35.3% Group 1; and 61.4%, 25%, 50%, and 18.2%, respectively, in Group 2 biopsies.
Higher rejection activity scores were more in Group 2.
Postbiopsy 1- and 5- year patient survival was 94.1%, 86.9% in Group 1 and 92.1%, 88.3% in Group 2; 1- and 4-year graft survival was 52.9%, 15.9% in Group 1 and 20.3%, 5.4% in Group 2.
TMA was poor prognosticator for RT, especially under triple immunosuppression.
Antibody- mediated rejection and tacrolimus toxicity were more prone to TMA.
American Psychological Association (APA)
Vanikar, Aruna V.& Kanodia, Kamal V.& Suthar, Kamlesh S.& Patel, Rashmi D.& Nigam, Lovelesh A.& Thakkar, Umang G.…[et al.]. 2020. Thrombotic microangiopathy in a renal allograft : single-center Five-year experience. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 6, pp.1331-1343.
https://search.emarefa.net/detail/BIM-1252256
Modern Language Association (MLA)
Vanikar, Aruna V.…[et al.]. Thrombotic microangiopathy in a renal allograft : single-center Five-year experience. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 6 (Nov. / Dec. 2020), pp.1331-1343.
https://search.emarefa.net/detail/BIM-1252256
American Medical Association (AMA)
Vanikar, Aruna V.& Kanodia, Kamal V.& Suthar, Kamlesh S.& Patel, Rashmi D.& Nigam, Lovelesh A.& Thakkar, Umang G.…[et al.]. Thrombotic microangiopathy in a renal allograft : single-center Five-year experience. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 6, pp.1331-1343.
https://search.emarefa.net/detail/BIM-1252256
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references : p. 1342-1343
Record ID
BIM-1252256