Meropenem at recommended dose is a potential risk for seizure in hemodialysis patient

Joint Authors

Musa, Dujanah
al-Huwaysh, Amani
Buhayri, Hisham
Skiker, Sami
al-Khalidi, Dalal
al-Duwayhi, Azizah
Abd al-Khani, Abd al-Nasir
Radi, Marwah
al-Hwish, Abd Allah
Abd al-Rahman, Ibrahim Said
al-Qahtani, Sad
al-Harbi, Ali

Source

Saudi Journal of Kidney Diseases and Transplantation

Issue

Vol. 31, Issue 6 (31 Dec. 2020), pp.1427-1431, 5 p.

Publisher

Saudi Center for Organ Transplantation

Publication Date

2020-12-31

Country of Publication

Saudi Arabia

No. of Pages

5

Main Subjects

Medicine

Abstract EN

Dosage adjustment of meropenem is usually recommended in hemodialysis (HD) patients and about 30% of meropenem is cleared during regular HD sessions.

However, most of the published trials excluded patients on regular HD.

Little is known about the accurate dosage of meropenem needed to avoid central nervous system toxicity.

Herein, we report a 65-year-old Saudi female, a known case of end-stage renal disease on regular HD, who was admitted because of pyelonephritis and started on meropenem in the recommended dose according to cultures and sensitivity.

She developed tonic-clonic convulsions after the 7th dose.

Seizures were completely aborted after discontinuation of the offending drug.

The recommended dosage of 500 mg daily in HD patients may still be too high particularly in Asian patients owing to their relatively small body mass index.

American Psychological Association (APA)

al-Hwish, Abd Allah& Abd al-Rahman, Ibrahim Said& al-Harbi, Ali& Musa, Dujanah& Buhayri, Hisham& al-Qahtani, Sad…[et al.]. 2020. Meropenem at recommended dose is a potential risk for seizure in hemodialysis patient. Saudi Journal of Kidney Diseases and Transplantation،Vol. 31, no. 6, pp.1427-1431.
https://search.emarefa.net/detail/BIM-1252664

Modern Language Association (MLA)

al-Hwish, Abd Allah…[et al.]. Meropenem at recommended dose is a potential risk for seizure in hemodialysis patient. Saudi Journal of Kidney Diseases and Transplantation Vol. 31, no. 6 (Nov. / Dec. 2020), pp.1427-1431.
https://search.emarefa.net/detail/BIM-1252664

American Medical Association (AMA)

al-Hwish, Abd Allah& Abd al-Rahman, Ibrahim Said& al-Harbi, Ali& Musa, Dujanah& Buhayri, Hisham& al-Qahtani, Sad…[et al.]. Meropenem at recommended dose is a potential risk for seizure in hemodialysis patient. Saudi Journal of Kidney Diseases and Transplantation. 2020. Vol. 31, no. 6, pp.1427-1431.
https://search.emarefa.net/detail/BIM-1252664

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references : p. 1431

Record ID

BIM-1252664